Summary
We evaluated the effect of TJS-010, a new prescription of oriental medicine, on hypothermia and flat body posture in rats, induced by activation of serotonin (5-HT)-1A receptors by (±)-8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT). Hypothermia was induced by 8-OH-DPAT in a dose and time-dependent manner. The hypothermia induced by O.1mg/kg 8-OH-DPAT was enhanced by 500 and 750mg/kg of TJS-010. At the concentration of O.1 mg/kg, 8-OH-DPAT also produced flat body posture in rats, and 750mg/ kg TJS-010 increased the flat body posture. These results suggest that TJS-010 facilitates the 5-HT-1A receptors in the central nervous system.
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Abbreviations
- 8-OH-DPAT :
-
(±)-8-hydroxy-2-(di-N-propylamino)tetralin
- 5-HT :
-
5-hydroxy-tryptamine(serotonin)
- ACTH :
-
adrenocorticotropic hormone
- CNS :
-
central nervous system
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Kagaya, A., Tanra, A.J., Shinno, H. et al. TJS-010, a new prescription of oriental medicine, enhances 8-OH-DPAT-induced effects in rats. J. Neural Transmission 103, 69–75 (1996). https://doi.org/10.1007/BF01292617
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DOI: https://doi.org/10.1007/BF01292617