Skip to main content
Log in

Effect of sleep deprivation on the growth hormone response to the alpha-2 adrenergic receptor agonist, clonidine, in normal subjects

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

One night's sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (2 ug/kg iv) in 11 normal men (p < 0.005). This finding may indicate that SD enhances alpha-2 adrenergic receptor function or that the GH response to GH releasing factor is increased by SD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abel MS, Villegas F, Abreu J, Gimino F, Steiner S, Beer B, Meyerson LR (1983) The effect of rapid eye movement sleep deprivation on cortical beta-adrenergic receptors. Brain Res Bull 11: 729–734

    PubMed  Google Scholar 

  • Abelson JL, Glitz D, Cameron OG, Lee MA, Bronzo M, Curtis GC (1991) Blunted growth hormone response to clonidine in patients with generalized anxiety disorder. Arch Gen Psychiatry 48: 157–162

    PubMed  Google Scholar 

  • Asakura W, Matsumoto K, Ohta H, Watanabe H (1993) Effect of alpha 2-adrenergic drugs on REM sleep deprivation-induced increase in swimming activity. Pharmacol Biochem Behav 46: 111–115

    PubMed  Google Scholar 

  • Asakura W, Matsumoto K, Ohta H, Watanabe H (1994) Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test. Pharmacol Biochem Behav 49: 79–84

    PubMed  Google Scholar 

  • Asikainen M, Deboer T, Porkka-Heiskanen T, Stenberg D, Tobler I (1995) Sleep deprivation increases brain serotonin turnover in the Djungarian hamster. Neurosci Lett 198: 21–24

    PubMed  Google Scholar 

  • Asnis GM, McGinn LK, Sanderson WC (1995) Atypical depression: clinical aspects and noradrenergic function. Am J Psychiatry 152: 31–36

    PubMed  Google Scholar 

  • Balldin J, Berggren U, Lindstedt G, Modigh K (1992) Neuroendocrine evidence for decreased function of alpha 2-adrenergic receptor after electroconvulsive therapy. Psychiatry Res 41: 257–265

    PubMed  Google Scholar 

  • Best NR, Rees MP, Barlow DH, Cowen PJ (1992) Effect of estradiol implant on noradrenergic function and mood in menopausal subjects. Psychoneuroendocrinology 17: 87–93

    PubMed  Google Scholar 

  • Calil HM, Zwicker AP (1987) Effects of desipramine and total sleep deprivation on hormonal levels of healthy subjects. Psychiatry Res 21: 337–348

    PubMed  Google Scholar 

  • Coupland N, Glue P, Nutt DJ (1992) Challenge tests: assessment of the noradrenergic and GABA systems in depression and anxiety disorders. Mol Aspects Med 13: 221–247

    PubMed  Google Scholar 

  • Davidson JR, Moldofsky H, Lue FA (1991) Growth hormone and cortisol secretion in relation to sleep and wakefulness. J Psychiat Neurosci 16: 96–102

    Google Scholar 

  • Demontis MG, Fadda P, Devoto P, Martellotta MC, Fratta W (1990) Sleep deprivation increases dopamine D1 receptor antagonist [3H]SCH 23390 binding and dopamine-stimulated adenylate cyclase in the rat limbic system. Neurosci Lett 117: 224–227

    PubMed  Google Scholar 

  • Ebert D, Kaschka WP, Loew T, Beck G (1994) Cortisol and beta-endorphin responses to sleep deprivation in major depression — the hyper arousal theories of sleep deprivation. Neuropsychobiology 29: 64–68

    PubMed  Google Scholar 

  • Glue P, Sellman JD, Nicholls MG, Abbott R, Joyce PR, Nutt DJ (1989) Studies of alpha-2-adrenoceptor function inabstinent alcoholics. Br J Addict 84: 97–102

    PubMed  Google Scholar 

  • Guyda H (1975) Heterogeneity of human growth hormone and prolactin secretion in vitro: immunoassay and radio-receptor assay correlations. J Clin Endocrinol Metab 41: 953–967

    PubMed  Google Scholar 

  • Hollander E, DeCaira C, Nitescu A, Cooper T, Stover B, Gully R, Klein DF, Liebowitz MR (1991) Noradrenergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to clonidine and comparison to healthy controls. Psychiatry Res 37: 161–177

    PubMed  Google Scholar 

  • Kuhs H, Tolle R (1991) Sleep deprivation therapy. Biol Psychiatry 29: 1129–1148

    PubMed  Google Scholar 

  • Lal S, Martin JB (1980) Neuroanatomy and neuropharmacological regulation of neuroendocrine function. In: Van Praag HM, Lader MH, Rafaelsen OJ, Sachar EJ (eds) Handbook of biological psychiatry, vol 3. Marcel Dekker, New York, pp 101–167

    Google Scholar 

  • Lal S, Tolis G, Martin JB, Brown GM, Guyda H (1975) Effect of clonidine on growth hormone, prolactin, luteinizing hormone, follicle stimulating hormone and thyroid stimulating hormone in the serum of normal men. J Clin Endocrinol Metab 41: 827–832

    PubMed  Google Scholar 

  • Lal S, Tolis G, McDonald TJ, Cervantes P, Dupré J (1981a) Effect of clonidine on growth hormone and glucagon secretion. Horm Metab Res 13: 648–649

    PubMed  Google Scholar 

  • Lal S, Thavundayil JX, Nair NPV, Etienne P, Rastogi R, Schwartz G, Pulman J, Guyda H (1981b) Effect of sleep deprivation on dopamine receptor function in normal subjects. J Neural Transm 50: 39–45

    PubMed  Google Scholar 

  • Lal S, Nair NPV, Thavundayil JX, Monks RC, Guyda H (1983) Clonidine-induced growth hormone secretion in chronic schizophrenia. Acta Psychiatr Scand 68: 82–88

    PubMed  Google Scholar 

  • Lal S, Thavundayil JX, Krishnan B, Nair NPV, Schwartz G, Guyda H (1996) The effect of yohimbine, an alpha2 adrenergic receptor antagonist, on the growth hormone response to apomorphine in normal subjects. J Psychiat Neurosci 21: 96–100

    Google Scholar 

  • Leibenluft E, Wehr TA (1992) Is sleep deprivation useful in the treatment of depression? Am J Psychiatry 149: 159–168

    PubMed  Google Scholar 

  • Matussek N, Ackenheil M, Hippius H, Muller F, Schröder HT, Schultes H, Wasilewski B (1980) Effect of clonidine on growth hormone release in psychiatrie patients and controls. Psychiatry Res 2: 25–36

    PubMed  Google Scholar 

  • Mazza E, Ghigo E, Bellone J, Arvat E, Revelli E, Cella SG, Brambilla F, Muller EE, Camanni F (1990) Effects of alpha- and beta-adrenergic agonists and antagonists on growth hormone secretion in man. Endocrinol Experiment 24: 211–219

    Google Scholar 

  • Mogilnicka E, Pilc A (1981) Rapid eye movement sleep deprivation inhibits clondine-induced sedation in rats. Eur J Pharmacol 71: 123–126

    PubMed  Google Scholar 

  • Muller N, Putz A, Klages U, Hofschuster E, Straube A, Ackenheil M (1994) Blunted growth hormone response to clonidine in Gilles de la Tourette syndrome. Psychoneuroendocrinology 19: 335–341

    PubMed  Google Scholar 

  • Muller HU, Riemann D, Berger M, Muller WE (1993) The influence of total sleep deprivation on urinary excretion of catecholamine metabolities in major depression. Acta Psychiatr Scand 88: 16–20

    PubMed  Google Scholar 

  • Nunes Junior GP, Tufik S, Nobrega JN (1994) Decreased muscarinic receptor binding in rat brain after paradoxical sleep deprivation: an autoradiographic study. Brain Res 645: 247–252

    PubMed  Google Scholar 

  • Pitchot W, Ansseau M, Gonzalez Moreno A, Wauthy J, Hansenne M, von Frenckell R (1994) Relationship between alpha 2-adrenergie function and suicidal behaviour in depressed patients. Psychiatry Res 52: 115–123

    PubMed  Google Scholar 

  • Porkka-Heiskanen T, Smith SE, Taira T, Urban JH, Levine JE, Turek FW, Stenberg D (1995) Noradrenergic activity in rat brain during rapid eye movement sleep deprivation and rebound sleep. Am J Physiol 268 (6 Pt 2): R1456-R1463

    PubMed  Google Scholar 

  • Potter WZ, Manji HK (1994) Catecholamines in depression: an update. Clin Chem 40: 279–287

    PubMed  Google Scholar 

  • Radomski MW, Hart LE, Goodman JM, Plyley MJ (1992) Aerobic fitness and hormonal responses to prolonged sleep deprivation and sustained mental work. Aviat Space Environment Med 63: 101–106

    Google Scholar 

  • Salin-Pascual RJ, Ortega-Soto H, Huerto-Delgadillo L, Camacho-Arroyo I, Roldan-Roldan G, Tamarkin L (1988) The effect of total sleep deprivation on plasma melatonin and cortisol in healthy human volunteers. Sleep 11: 362–369

    PubMed  Google Scholar 

  • Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122: 509–522

    PubMed  Google Scholar 

  • Siegel JM, Rogawski MA (1988) A function for REM sleep: regulation of noradrenergic sensitivity. Brain Res 472: 213–233

    PubMed  Google Scholar 

  • Siever LJ, Uhde TW, Silberman ER, Jimerson DC, Aloi JA, Post RM, Murphy DL (1982) Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls. Psychiatry Res 6: 171–183

    PubMed  Google Scholar 

  • Siever LJ, Insel TR, Jimerson DC, Lake CR, Uhde TW, Aloi J, Murphy DL (1983) Growth hormone response to clonidine in obsessive-compulsive patients. Br J Psychiatry 142: 184–187

    PubMed  Google Scholar 

  • Tononi G, Pompeiano M, Cirelli C (1994) The locus coeruleus and immediate-early genes in spontaneous and forced wakefulness. Brain Res Bull 35: 589–596

    PubMed  Google Scholar 

  • Troncone LR, Braz S, Benedito MA, Tufik S (1986) REM sleep deprivation induces a decrease in norepinephrine-stimulated3H-cyclic AMP accumulation in slices from rat brain. Pharmacol Biochem Behav 25: 223–225

    PubMed  Google Scholar 

  • Tsai LL, Bergmann BM, Perry BD, Rechtschaffen A (1993) Effects of chronic total sleep deprivation on central noradrenergic receptors in rat brain. Brain Res 602: 221–227

    PubMed  Google Scholar 

  • Tulandi T, Lal S, Guyda H (1987) Effect of estrogen on the growth hormone response to the α-adrenergic agonist, clonidine, in women with menopausal flushing. J Clin Endocrinol Metab 65: 6–10

    PubMed  Google Scholar 

  • Vogel GW, Thurmond A, Gibbons P, Sloan K, Walker M (1975) REM sleep reduction effects on depression syndromes. Arch Gen Psychiatry 32: 765–777

    PubMed  Google Scholar 

  • Wu JC, Bunney WE (1990) The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis. Am J Psychiatry 147: 14–21

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lal, S., Thavundayil, J.X., Krishnan, B. et al. Effect of sleep deprivation on the growth hormone response to the alpha-2 adrenergic receptor agonist, clonidine, in normal subjects. J. Neural Transmission 104, 291–298 (1997). https://doi.org/10.1007/BF01273189

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01273189

Keywords

Navigation