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Age-related changes in the cerebrospinal fluid level of β-endorphin and substance P

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Summary.

To evaluate the early age-related changes in neuropeptides, we have measured the cerebrospinal fluid (CSF) levels of β-endorphin and substance P in young patients over a range of ages. Specimens of CSF were obtained from 39 neurologically normal children, aged 1 month to 10 years of age, and in 9 adult controls. CSF levels of both neuropeptides were observed to peak during the first year of life, and showed a negative correlation with increasing age. A significant positive correlation was observed between the CSF level of β-endorphin and that of substance P.

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Authors and Affiliations

  1. Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume,, , , , ,

    S. Nagamitsu, T. Matsuishi, H. Komori, Y. Yamashita, H. Eguchi & H. Kato

  2. Department of Pediatrics, Emergency Medical Center, Kitakyushu City Yahata Hospital, Kitakyusyu, and, , , , ,

    K. Ichikawa

  3. Fujimoto Children's Hospital, Ohita, Japan, , , , , , JP

    T. Fujimoto

Authors
  1. S. Nagamitsu
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  2. T. Matsuishi
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  3. H. Komori
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  4. Y. Yamashita
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  5. H. Eguchi
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  6. K. Ichikawa
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  7. T. Fujimoto
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  8. H. Kato
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Accepted November 11, 1997 / Received July 31, 1997

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Nagamitsu, S., Matsuishi, T., Komori, H. et al. Age-related changes in the cerebrospinal fluid level of β-endorphin and substance P. J Neural Transm 105, 53–58 (1998). https://doi.org/10.1007/s007020050037

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  • DOI: https://doi.org/10.1007/s007020050037

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