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Plasma dehydroepiandrosterone sulfate in unipolar major depression

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Summary.

We investigated plasma dehydroepiandrosterone sulfate (DHEAS) and cortisol levels in 12 patients with unipolar depression and 11 matched normal controls. The depressed patients showed significantly higher values of plasma DHEAS and cortisol than the controls. After 4 weeks of treatment with antidepressants (mainly clomiplamine), the high plasma DHEAS levels recovered.

This finding showed the possible relationship between plasma DHEAS levels and depression, as well as cortisol levels.

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Authors and Affiliations

  1. Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima, and, , , , ,

    M. Takebayashi, A. Kagaya, M. Muraoka, N. Yokota, J. Horiguchi & S. Yamawaki

  2. Psycho-Oncology Division, National Cancer Center Research Institute East, Kashiwa, Japan, , , , , , JP

    Y. Uchitomi & A. Kugaya

Authors
  1. M. Takebayashi
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  2. A. Kagaya
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  3. Y. Uchitomi
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  4. A. Kugaya
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  5. M. Muraoka
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  6. N. Yokota
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  7. J. Horiguchi
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  8. S. Yamawaki
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Accepted February 10, 1998; received July 17, 1997

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Takebayashi, M., Kagaya, A., Uchitomi, Y. et al. Plasma dehydroepiandrosterone sulfate in unipolar major depression . J Neural Transm 105, 537–542 (1998). https://doi.org/10.1007/s007020050077

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  • DOI: https://doi.org/10.1007/s007020050077

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