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Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis

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Summary.

To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls.

These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.

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Authors and Affiliations

  1. Department of Pediatrics and Child Health, and, , , , ,

    T. Matsuishi, S. Nagamitsu, Y. Yamashita & H. Kato

  2. First Department (Neurology) of Internal Medicine, Kurume University School of Medicine, Fukuoka,, , , , ,

    H. Shoji

  3. Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Tokyo,, , , , ,

    M. Itoh & S. Takashima

  4. Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, and, , , , ,

    T. Iwaki

  5. Department of Neurology, National Chikugo Hospital, Fukuoka, Japan, , , , , , JP

    N. Shida & T. Sakai

Authors
  1. T. Matsuishi
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  2. S. Nagamitsu
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  3. H. Shoji
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  4. M. Itoh
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  5. S. Takashima
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  6. T. Iwaki
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  7. N. Shida
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  8. Y. Yamashita
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  9. T. Sakai
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  10. H. Kato
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Additional information

Received January 30, 1999; accepted June 15, 1999

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Matsuishi, T., Nagamitsu, S., Shoji, H. et al. Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis. J Neural Transm 106, 943–948 (1999). https://doi.org/10.1007/s007020050214

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  • DOI: https://doi.org/10.1007/s007020050214

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