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Extrapontine myelinolysis with parkinsonism after rapid correction of hyponatremia: high cerebrospinal fluid level of homovanillic acid and successful dopaminergic treatment

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Summary.

Extrapontine myelinolysis (EPM) is a demyelinating process of the brain. We report the case of an 11-year-old girl who developed EPM with parkinsonism. Magnetic resonance imaging revealed demyelinating patterns in the basal ganglia without central pontine lesions. The cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid were high at the time of onset and normalized upon complete recovery from extrapyramidal symptoms after a dopaminergic treatment.

We speculated that demyelination of nerve fibers containing dopamine receptors in the striatum might be a main cause of these symptoms.

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Authors and Affiliations

  1. Department of Pediatrics and Child Health, and, , , , ,

    S. Nagamitsu, T. Matsuishi, Y. Yamashita & H. Kato

  2. Institute of Brain Disease, Kurume University School of Medicine, Kurume, Japan, , , , , , JP

    S. Yamada

Authors
  1. S. Nagamitsu
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  2. T. Matsuishi
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  3. Y. Yamashita
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  4. S. Yamada
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  5. H. Kato
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Received December 2, 1998; accepted May 6, 1999

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Nagamitsu, S., Matsuishi, T., Yamashita, Y. et al. Extrapontine myelinolysis with parkinsonism after rapid correction of hyponatremia: high cerebrospinal fluid level of homovanillic acid and successful dopaminergic treatment. J Neural Transm 106, 949–953 (1999). https://doi.org/10.1007/s007020050215

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  • DOI: https://doi.org/10.1007/s007020050215

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