Summary
Danitracen lowered serotonin levels in the cerebrum, cerebellum, medulla and the whole brain. The drug did not appear to affect the concentration of 5-HIAA except in the cerebellum where there was a considerable depletion. Danitracen pretreatment led to a lowering in the 5-HT levels in the various parts of the brain without influencing 5-HIAA levels in the whole brain and decreased NE levels in apomorphine and amphetamine-treated rats. The findings indicate that the mechanism of action of danitracen also involves noradrenergic neurons along with a possible increase in the metabolism of 5-HT.
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Hrishi Keshavan, H.J., Gurbani, N.K. & Dandiya, P.C. Neurochemical effects of danitracen (WA-355): Mechanism of action. J. Neural Transmission 53, 217–221 (1982). https://doi.org/10.1007/BF01243413
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DOI: https://doi.org/10.1007/BF01243413