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Initiation of visual-guided random saccades and remembered saccades in parkinsonian patients with severe motor-fluctuations

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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

Summary

We studied the initiation of saccades to visual-guided random time and remembered targets in a group of nine Parkinsonian patients with severe motor fluctuations and in 9 age matched control subjects. In contrast to a marked skeletomotor improvement during the “on” condition, saccadic latencies for both visual-guided random saccades and remembered saccades were increased in the patients during the “on” condition compared to the “off” condition. This result of dissociation between skeletomotor and oculomotor function indicates that common concepts of saccadic initiation in parkinsonian patients do not hold true in patients with severe fluctuations since dopaminergic stimulation seems to increase saccadic latencies in these patients.

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Author notes

  1. Ch. Müller

    Present address: Universitätsklinik für Neurologie, Währinger Gürtel 18-20, A-1090, Vienna, Austria

Authors and Affiliations

  1. Department of Neurological Rehabilitation, University of Vienna, Austria

    Ch. Müller, L. Fertl & E. Auff

  2. Clinical Neurology, University of Vienna, Austria

    S. Wenger

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  1. Ch. Müller
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  2. S. Wenger
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  3. L. Fertl
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  4. E. Auff
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Müller, C., Wenger, S., Fertl, L. et al. Initiation of visual-guided random saccades and remembered saccades in parkinsonian patients with severe motor-fluctuations. J Neural Transm Gen Sect 7, 101–108 (1994). https://doi.org/10.1007/BF02260964

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  • DOI: https://doi.org/10.1007/BF02260964

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