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Subtype H7 influenza viruses: comparative antigenic and molecular analysis of the HA-, M-, and NS-genes

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Summary

Antigenic analysis of the haemagglutinin and matrix protein with corresponding sets of monoclonal antibodies as well as sequence analysis of HA-, M-, and NS-genes were carried out to establish antigenic and genetic relationships between four fowl plague virus (FPV) strains of H7 subtype. The data obtained revealed close genetic relatedness between the oldest known influenza A virus, A/chicken/Brescia/1902 (H7N7), and two FPV strains, A/FPV/Dobson (H7N7) and A/FPV/Weybridge (H7N7). These three strains apparently differ in all genes investigated from the A/FPV/Rostock isolate.

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Authors and Affiliations

  1. Research Institute for Viral Preparations, Academy of Medical Sciences of the U.S.S.R., Moscow, U.S.S.R

    A. Klimov

  2. Institute of Virology, Charité, Humbold University, Berlin, Germany

    S. Prösch

  3. Bundesgesundheitsamt, Insitute of Viral Zoonoses, Potsdam, Germany

    J. Schäfer

  4. New York Medical College, Valhalla, New York, USA

    D. Bucher

Authors
  1. A. Klimov
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  2. S. Prösch
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  3. J. Schäfer
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  4. D. Bucher
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Klimov, A., Prösch, S., Schäfer, J. et al. Subtype H7 influenza viruses: comparative antigenic and molecular analysis of the HA-, M-, and NS-genes. Archives of Virology 122, 143–161 (1992). https://doi.org/10.1007/BF01321124

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  • DOI: https://doi.org/10.1007/BF01321124

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