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Human immunodeficiency virus type 1 (HIV-1) and human hematopoietic progenitor cells

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Summary

Besides a progressive depletion of CD4+ T-lymphocytes, other peripheral blood cytopenias, (granulocytopenia, anemia and thrombocytopenia) are frequently observed in HIV-1 seropositive individuals, especially in patients with overt AIDS. Various experimental evidences suggest that HIV-1 could play a direct role in the pathogenesis of HIV-1 related peripheral blood cytopenias, affecting the survival/proliferation capacity of hematopoietic progenitors. CD34+ human hematopoietic progenitors, however, are substantially not susceptible to HIV-1 infection either in vitro and in vivo and their defects seem rather related to an alteration of bone marrow and peripheral blood microenvironments due to the presence of soluble HIV-1 specific products.

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  1. St. Orsola General Hospital, Institute of Microbiology of the University of Bologna, Bologna, Italy

    M. C. Re, G. Furlini, G. Zauli & M. La Placa

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Re, M.C., Furlini, G., Zauli, G. et al. Human immunodeficiency virus type 1 (HIV-1) and human hematopoietic progenitor cells. Archives of Virology 137, 1–23 (1994). https://doi.org/10.1007/BF01311169

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