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Envelope gene sequences of human T-lymphotropic virus type I in Taiwan

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Summary

Three major types of HTLV-I had been proposed, the Melanesian type, the Zairian type, and the cosmopolitan type, which was further divided into subtypes A, B and C, according to the phylogenetic tree constructed from LTR sequences of current HLTV-I isolates. In this study, the envelope gene sequences of HTLV-I from 9 Taiwanese were analyzed. Based on the phylogenetic tree constructed by unweighed pair group method and the sequence homology analysis by GCG computer programs, the envelope gene sequences of HTLV-I proviruses from these 9 Taiwanese belonged to subtype A or subtype B of the cosmopolitan type and were closely related to HTLV-I from Japan. Twelve subtype-specific nucleotide variations were deduced from the comparison of complete or partial envelope gene sequences of 16 HTLV-I isolates of known subtypes as well as those of 9 Taiwanese. These data provided the basis for subtyping the cosmopolitan type of HTLV-I by amplification of envelope gene sequences and restriction fragment length polymorphism studies. A more extensive survey based upon this proposal was warranted.

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Authors and Affiliations

  1. Department of Oncology, National Taiwan University Hospital, Taiwan

    M. T. Lin & J. M. Wu

  2. Department of Laboratory Medicine, National Taiwan University Hospital, Taiwan

    Y. C. Chen

  3. Department of Internal Medicine, National Taiwan University Hospital, Taiwan

    P. J. Chen

  4. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

    Y. C. Yang & C. S. Yang

  5. Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

    Y. C. Yang

  6. School of Medical Technology, College of Medicine, National Taiwan University, Taipei, Taiwan

    J. L. Tang

  7. Cancer Research Center, College of Medicine, National Taiwan University, Taipei, Taiwan

    S. E. Chuang

Authors
  1. M. T. Lin
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  2. Y. C. Chen
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  3. P. J. Chen
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  4. Y. C. Yang
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  5. J. L. Tang
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  6. J. M. Wu
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  7. S. E. Chuang
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  8. C. S. Yang
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Lin, M.T., Chen, Y.C., Chen, P.J. et al. Envelope gene sequences of human T-lymphotropic virus type I in Taiwan. Archives of Virology 141, 219–229 (1996). https://doi.org/10.1007/BF01718395

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  • DOI: https://doi.org/10.1007/BF01718395

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