Summary
Serums of swine inoculated with chemically-treated foot-and-mouth disease virus (FMDV) combined with an oil adjuvant had an enduring level of antibody and the swine were resistant to challenge by exposure to FMD-infected swine for at least 90 days. The antibody level was significantly higher in the animals inoculated with the treated virus and oil adjuvant than in the animals inoculated with the treated virus and aluminium hydroxide adjuvant as indicated by analysis of variance of mouse protective dose (PD50) values. Swine recovered from experimental infection with FMDV may become reinfected when exposed to homologous virus.
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This study is based on part of a dissertation submitted by the senior author in partial fulfillment of the requirements for the DVSc. degree, Graduate School, University of Toronto, Toronto, Ontario, Canada.
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McKercher, P.D., Giordano, A.R. Foot-and-mouth disease in swine. Archiv f Virusforschung 20, 39–53 (1967). https://doi.org/10.1007/BF01245768
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DOI: https://doi.org/10.1007/BF01245768