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Development of a cell culture system susceptible to measles, canine distemper, and rinderpest viruses

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Summary

Three strains of chick embryo adapted canine distemper virus (Lederle, Wisconsin, and Onderstepoort strains) and chick embryo adapted LA strain of rinderpest virus were easily adapted to an established line of African green monkey kidney cells (Vero cells), which has been routinely employed for the titration of measles virus. By using these Vero cell adapted strains of canine distemper and rinderpest viruses, techniques of infectivity titration and virus neutralization in Vero cells were established. Comparative studies of cytopathology and growth characteristics of canine distemper, rinderpest, and measles viruses indicated that the behavior of the three viruses in Vero cells is almost the same. The Vero cell system was suggested as a suitable host for the comparative study of the serologic and biologic relationships among measles, canine distemper, and rinderpest viruses.

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References

  1. Bussell, R. H., andD. T. Karzon: Canine distemper virus in chick embryo cell culture. Plaque assay, growth, and stability. Virology18, 589–600 (1962).

    Google Scholar 

  2. Bussell, R. H., andD. T. Karzon: Canine distemper virus in ferret, dog and bovine kidney cell cultures. Arch. ges. Virusforsch.17, 163–182 (1965).

    Google Scholar 

  3. Bussell, R. H., andD. T. Karzon: Canine distemper virus in primary and continuous cell lines of human and monkey origin. Arch. ges. Virusforsch.17, 183–202 (1965).

    Google Scholar 

  4. Cabasso, V. J., K. Kiser, andM. R. Stebbins: Propagation of canine distemper (CD) virus in tissue culture. Proc. Soc. exp. Biol. (N. Y.)100, 551–554 (1959).

    Google Scholar 

  5. Carlström, G.: Comparative studies on measles and distemper viruses in suckling mice. Arch. ges. Virusforsch.8, 527–538 (1958).

    Google Scholar 

  6. Delay, P. D., S. S. Stone, D. T. Karzon, S. Katz, andJ. Enders: Clinical and immune response of alien hosts to inoculation with measles, rinderpest, and canine distemper viruses. Amer. J. vet. Res.26, 1359–1373 (1965).

    Google Scholar 

  7. Enders, J. F., andT. C. Peebles: Propagation in tissue cultures of cytopathogenic agents from patients with measles. Proc. Soc. exp. Biol. (N. Y.)86, 277–286 (1954).

    Google Scholar 

  8. Frankel, J. W., T. Burnstein, andM. K. West: Propagation of measles virus in tissue cultures of dog kidney cells. Fed. Proc.17, 511 (1958).

    Google Scholar 

  9. Haig, D. A.: Preliminary note on cultivation of Green's distemperoid virus in fertile hen eggs. Onderstepoort J. vet. Sci. Anim. Indust.23, 149–155 (1948).

    Google Scholar 

  10. Hull, R. N., W. R. Cherry, andO. J. Tritch: Growth characteristics of monkey kidney cell strains LLC-MK1, LLC-MK2, and LLC-MK2 (NCTC-3196) and their utility in virus research. J. exp. Med.115, 903–918 (1962).

    Google Scholar 

  11. Imagawa, D. T.: Propagation of rinderpest virus in suckling mice and its comparison to murine adapted strains of measles and distemper. Arch. ges. Virusforsch.17, 203–215 (1965).

    Google Scholar 

  12. Imagawa, D. T., andJ. M. Adams: Propagation of measles virus in suckling mice. Proc. Soc. exp. Biol. (N. Y.)98, 567–569 (1958).

    Google Scholar 

  13. Imagawa, D. T., C. D. Baird, andJ. M. Adams: Measles and distemper viruses in continuously cultured dog kidney cells. Fed. Proc.22, 488 (1963).

    Google Scholar 

  14. Imagawa, D. T., P. Goret, andJ. M. Adams: Immunological relationship of measles, distemper and rinderpest viruses. Proc. nat. Acad. Sci. (Wash.)46, 1119–1123 (1960).

    Google Scholar 

  15. Isogai, S.: Pathogenicity of rinderpest virus, original and attenuated, in various tissue cultures. J. Jap. Ass. infect. Dis.35, 417–432 (1961).

    Google Scholar 

  16. Karzon, D. T., andR. H. Bussell: Cytopathic effect of canine distemper virus in tissue culture. Science130, 1708–1709 (1959).

    Google Scholar 

  17. Katz, S. L., M. V. Milovanovic, andJ. F. Enders: Propagation of measles virus in cultures of chick embryo cells. Proc. Soc. exp. Biol. (N. Y.)97, 23–29 (1958).

    Google Scholar 

  18. Liess, B., andW. Plowright: The propagation and growth characteristics of rinderpest virus in HeLa cells. Arch. ges. Virusforsch.14, 27–38 (1964).

    Google Scholar 

  19. Matumoto, M.: Multiplication of measles virus in cell cultures. Bact. Rev.30, 152–176 (1966).

    Google Scholar 

  20. Matumoto, M., M. Mutai, H. Ogiwara, andM. Nakamura: Prolifération du virus rougeaux en culture de cellules rénales bovines. C. R. Soc. Biol. (Paris)155, 1192–1195 (1961).

    Google Scholar 

  21. Meyer, H. M., B. E. Brooks, R. D. Douglas, andN. G. Rogers: Potency testing of live measles vaccine. Amer. J. Dis. Child.103, 457–459 (1962).

    Google Scholar 

  22. Morse, H. G., T. L. Chow, andC. A. Brandly: Propagation of a strain of egg-adapted distemper virus in suckling mice. Proc. Soc. exp. Biol. (N. Y.)84, 10–12 (1953).

    Google Scholar 

  23. Musser, S. J., andE. A. Slater: Measles virus growth in canine renal cell cultures. Amer. J. Dis. Child.103, 476–481 (1962).

    Google Scholar 

  24. Nakamura, J., andT. Miyamoto: Avianization of lapinized rinderpest virus. Amer. J. vet. Res.14, 307–317 (1953).

    Google Scholar 

  25. Plowright, W.: Rinderpest virus. Ann. N. Y. Acad. Sci.101, 548–563 (1962).

    Google Scholar 

  26. Plowright, W., andR. D. Ferris: Studies with rinderpest virus in tissue culture. I. Growth and cytopathogenicity. J. comp. Path.69, 152–172 (1959).

    Google Scholar 

  27. Rockborn, G.: Canine distemper virus in tissue culture. Arch. ges. Virusforsch.8, 485–492 (1958).

    Google Scholar 

  28. Rosen, L.: Haemagglutination and haemagglutination-inhibition with measles virus. Virology13, 139–141 (1961).

    Google Scholar 

  29. Ruckle-Enders, G.: Comparative studies of monkey and human measles virus strains. Amer. J. Dis. Child.103, 297–307 (1962).

    Google Scholar 

  30. Singh, K. V., andI. F. ElCicy: Comparative cytopathology of rinderpest and bovine parainfluenza 3 viruses in cell cultures. Nature (Lond.)211, 314–315 (1966).

    Google Scholar 

  31. Toyoshima, K., S. Hata, M. Takahashi, T. Miki, andY. Okuno: Virological studies on measles virus. III. Morphological changes and virus growth in FL cultures. Biken's J.3, 241–248 (1960).

    Google Scholar 

  32. Warren, J.: The relationships of the viruses of measles, canine distemper, and rinderpest. Advanc. Virus Res.7, 27–60 (1960).

    Google Scholar 

  33. Waterson, A. P., R. Rott, andG. Ruckle-Enders: The components of measles virus and their relation to rinderpest and distemper. Z. Naturforsch.18, 377–384 (1963).

    Google Scholar 

  34. West, J. L., S. H. McNutt, andC. A. Brandly: Adaptation of fox distemper virus to embryonating chicken eggs. Cornell Vet.46, 39–50 (1956).

    Google Scholar 

  35. Wright, J.: Cytopathic effect on primate and rodent tissue-cultures of agent isolated from measles patient. Lancet272, 669–670 (1957).

    Google Scholar 

  36. Yasumara, Y., andY. Kawatika: Studies on SV40 virus in tissue cultures. Nihon Rinsho21, 1201–1215 (1963) (in Japanese).

    Google Scholar 

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Author notes

  1. A. Shishido

    Present address: Department of Measles Virus, National Institute of Health, Tokyo, Japan

Authors and Affiliations

  1. Department of Measles Virus, National Institute of Health, Tokyo, Japan

    K. Yamanouchi, M. Hikita, T. Sato, A. Fukuda & F. Kobune

Authors
  1. A. Shishido
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  2. K. Yamanouchi
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  3. M. Hikita
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  4. T. Sato
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  5. A. Fukuda
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Shishido, A., Yamanouchi, K., Hikita, M. et al. Development of a cell culture system susceptible to measles, canine distemper, and rinderpest viruses. Archiv f Virusforschung 22, 364–380 (1967). https://doi.org/10.1007/BF01242957

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  • DOI: https://doi.org/10.1007/BF01242957

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