Summary
The duration of immunity was studied for a 365-day period in swine vaccinated with a foot-and-mouth disease trivalent vaccine, inactivated for 48 hours with acetylethyleneimine and combined with an oil adjuvant. A satisfactory degree of immunity was afforded at 90 and 180 days postinoculation (DPI). At 365 DPI, vaccinated swine still maintained a degree of resistance to infection despite marked lowering of neutralizing antibody. At 6 months, lesions at inoculation sites were of very limited extent and appeared as scattered islands of small yellowish streaks of fibrous tissue and some spherical nodules. Histologically, lesions were multiple, foreign-body-type granulomas characterized by oil vacuoles, reticuloendothelial cell proliferation and fibrosis. Tissues surrounding lesions were normal. At 12 months, these lesions were almost impossible to locate. Microscopically, they were comparable to those observed at 6 months. Whether these lesions are more serious than those obtained with current products and other adjuvants and whether these constitute a carcass blemish remain to be determined.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Beveridge, W. I. B.: Viral and Rickettsial Infections of Animals. p. 335. New York: Academic Press, 1967.
Bogdan, J.: Vet. Med. (Praha)12, 565 (1967).
Brooksby, J. B.: Spec. Eep. Ser. Agric. Res. Coun. (London), No. 12, H.M.S.O. (1952).
Burrows, R.: Report Presented to the European Commission for the Control of Foot-and-Mouth Disease, Report of Standing Technical Committee, Pirbright, United Kingdom (1963).
Cowan, K. M., andR. Teautman: J. Immunol.99, 729 (1967).
Cunliffe, H. R., andJ. H. Graves: Canad. J. comp. Med.27, 193 (1963).
Edsall, G.: First International Conference on Vaccines Against Viral and Rickettsial Diseases of Man. Pan Amer. Hlth Org., Scientific Publication 147, May 1967.
Girard, M., B.Guilloteau, A.Perrot, C.Debrock, and P.Prunet: Bull. Off. int. Epiz., in press, 1969.
Graves, J. H.: J. Immunol.102, 58 (1969).
Graves, J. H., and R.Arlinghaus: Proc. U.S.L.S.A., 71st Ann. Mtg., p. 396 (1967).
Graves, J. H., P. D. McKercher, H. E. Farris, Jr., andK. M. Cowan: Res. Vet. Sci.9, 35 (1968).
Hardegree, M. C., andM. Pittman: Proc. Soc. exp. Biol. (N.Y.)123, 179 (1966).
Henderson, W. M.: J. Hyg. (Lond.)50, 195 (1952).
Laufer, A., C. Tal, andA. J. Behar: Brit. J. exp. Path.40, 1 (1959).
Lillie, R. D.: Histopathologic Technic and Practical Histochemistry. New York: McGraw-Hill Book Co., 1965.
McKerchee, P. D., andH. E. Farris, Jr.: Arch. ges. Virusforsch.22, 451 (1967).
McKercher, P. D., andA. R. Giordano: Arch. ges. Virusforsch.20, 39 (1967).
Morgan, D. O., P. D.McKercher, and H. L.Bachrach: Proc. U.S.L.S.A., 72nd Ann. Mtg., in press, 1969.
Peck, H. M., A. F. Woodhour, D. P. Metzgar, S. E. McKennet, andM. R. Hilleman: Proc. Soc. exp. Biol. (N.Y.)116, 523 (1964).
Potter, M., andC. R. Boyce: Nature (Lond.)193, 1086 (1962).
Potter, M., andJ. Robertson: J. nat. Cancer Inst.25, 847 (1961).
Prigal, S. J.: Ann. Allergy25, 449 (1967).
Steiner, J. W., B. Langer, andD. L. Schatz: Arch. Path.70, 424 (1960).
White, R. G., A. H. Coons, andJ. M. Connolly: J. exp. Med.102, 83 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McKercher, P.D., Gailiunas, P. Response of swine to inactivated foot-and-mouth disease vaccine. Archiv f Virusforschung 28, 165–176 (1969). https://doi.org/10.1007/BF01249381
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01249381