Summary
Seed stock of Newcastle disease virus (NDV) prepared by infecting primary chick embryo (PCE) cells (CE-NDV) induced interferon production in PCE cells. Unlike the case of egg-grown NDV (EG-NDV), UV irradiation of CE-NDV resulted in a linear decrease of interferon inducing potency. The interferon induction by CE-NDV was not a strain-specific characteristic, seemed to be associated with viral growth, and was interfered by an excess dose of EG-NDV in its very early period of infection. Little has been elucidated about the mechanism which governs the alteration between EG- and CE-NDV type of interferon stimulation.
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Kohno, S., Kohase, M. Studies on interferon induction by Newcastle disease virus (NDV). Archiv f Virusforschung 28, 177–187 (1969). https://doi.org/10.1007/BF01249382
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DOI: https://doi.org/10.1007/BF01249382