Skip to main content
SpringerLink
Log in

Thoracic lymph duct cannulation of mice infected with lymphocytic choriomeningitis (LCM) and ectromelia viruses

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

WEHI mice infected with LCM virus or with the virulent Hampstead mouse strain of ectromelia virus showed a decrease in the output of small lymphocytes from the thoracic duct. These infections were lethal, and caused thymic cortex depletion and fatty liver changes which were especially severe in the case of LCM virus infection. These changes were due to an adrenal-cortex mediated response. The fall in cell output from thoracic lymph could be attributed to the combined effects of the destruction of infected splenic and lymph node lymphocytes, and lymphocyte-destruction mediated by the corticosteroid stress response to infection.

In C57BL mice infected with LCM virus and in WEHI mice infected with the avirulent Hampstead egg strain of ectromelia virus there was no change in small lymphocyte output. These infections were non lethal, with no sickness, minimal stress changes, and little or no destruction of lymphocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mims, C. A., andS. Wainwright: The immunodepressive action of lymphocytic choriomeningitis virus in mice. J. Immunol.101, 717 (1968).

    Google Scholar 

  2. Fenner, F.: Mouse pox (infectious ectromelia of mice). Aust. J. exp. Biol. med. Sci.27, 31 (1949).

    Google Scholar 

  3. Mims, C. A.: Aspects of the pathogenesis of virus diseases. Bact. Rev.28, 30 (1964).

    Google Scholar 

  4. Mims, C. A., andF. Tosolini: Pathogenesis of lesions in lymphoid tissue of mice infected with lymphocytic choriomeningitis (LCM) virus. Brit. J. exp. Path.50, 584 (1969).

    Google Scholar 

  5. Schell, K.: Studies on the innate resistance of mice to infection with mousepox. I. Resistance and antibody production. Aust. J. exp. Biol. med. Sci.38, 271 (1960).

    Google Scholar 

  6. Wallnerova, Z., andC. A. Mims: Thoracic duct cannulation and hemal node formation in mice infected with cowpox virus. Brit. J. exp. Path.51, 118 (1970).

    Google Scholar 

  7. Tosolini, F. A., andC. A. Mims: Effect of mouse strain and virus strain on the pathogenesis of lymphocytic choriomeningitis infection with a study of footpad responses. J. infect. Dis.123, 134 (1971).

    Google Scholar 

Download references

Author information

Author notes

  1. Zlata Wallnerova

    Present address: Department of Virology, Research Institute of Epidemiology and Microbiology, Bratislava, Czechoslovakia

  2. C. A. Mims

    Present address: Department of Microbiology, John Curtin School of Medical Research, The Australian National University, Canberra, A.C.T., Australia

Authors and Affiliations

  1. Department of Microbiology, John Curtin School of Medical Research, The Australian National University, Canberra, A.C.T., Australia

    Zlata Wallnerova

Authors
  1. Zlata Wallnerova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. A. Mims
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wallnerova, Z., Mims, C.A. Thoracic lymph duct cannulation of mice infected with lymphocytic choriomeningitis (LCM) and ectromelia viruses. Archiv f Virusforschung 35, 152–160 (1971). https://doi.org/10.1007/BF01249706

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01249706

Keywords

Search

Navigation