Skip to main content
Log in

DNA-dependent DNA polymerase pattern in noninfected and herpesvirus infected rabbit kidney cells

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

In this paper we report on a DNA-dependent DNA polymerase produced in herpesvirus infected cells which is not present in virions. It differs from the polymerases of noninfected cells by its molecular weight as well as by its insensitivity to cytosine arabinoside triphosphate (ara-CTP).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Becker, Y., andY. Chen: The reaction of vaccinia virus with deoxycholate. Israel J. med. Sci.2, 417 (1966).

    PubMed  Google Scholar 

  2. Bollum, F. J.: Filter paper disc techniques for assaying radioactive macromolecules. In: Procedures in Nucleic Acid Research, pp. 284–295 (I. G. Cantoni andD. R. Davis, eds.), New York-London: Harper and Row, 1966.

    Google Scholar 

  3. Buthala, D. A.: Cell culture studies on antiviral agents: I. Action of cytosine arabinoside and some comparisons with 5-Iodo-2-Deoxyuridine. Proc. Soc. exp. Biol. (N.Y.)115, 69 (1964).

    Google Scholar 

  4. Chang, L. M. S., andF. J. Bollum: Low molecular weight deoxyribonucleic acid polymerase in mammalian cells. J. biol. Chem.246, 5835 (1971).

    PubMed  Google Scholar 

  5. Determann, H.: Gelchromatographie, p. 116. Berlin-Heidelberg-New York: Springer, 1967.

    Google Scholar 

  6. Falke, D.: Ca++, Histidin und Zn++ als Faktoren bei der Riesenzellbildung durch Herpesvirus hominis. Z. med. Mikrobiol. Immunol.153, 175 (1967).

    PubMed  Google Scholar 

  7. Falke, D., B. Heicke, andR. Bässler: The effect of arabinofuranosyl-cytosine upon the synthesis of herpesvirus hominis. Arch. ges. Virusforsch.39, 48 (1972).

    PubMed  Google Scholar 

  8. Graham, B. J., H. Ludwig, D. L. Bronson, M. Benyesh-Melnick, andN. Biswal: Physicochemical properties of the DNA of herpes viruses. Biochim. biophys. Acta (Amst.)259, 13 (1972).

    Google Scholar 

  9. Keir, H. M., andE. Gold: Deoxyribonucleic acid nucleotidyltransferase and deoxyribonuclease from culture and cells infected with herpes simplex virus. Biochim. biophys. Acta (Amst.)72, 263 (1963).

    Google Scholar 

  10. Keir, H. M.: DNA polymerases from mammalian cells. In: Progress in Nucleic Acid Research and Molecular Biology4, 81–128. (J. N. Davidson andW. E. Cohen, eds.) New York-London: Academic Press, 1965.

    Google Scholar 

  11. Keir, H. M., J. Hay, J. M. Morrison, andH. Subak-Sharpe: Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus. Nature (Lond.)210, 369 (1966).

    Google Scholar 

  12. Keir, H. M., H. Subak-Sharpe, W. I. H. Shedden, D. H. Watson, andP. Wildy: Immunological evidence for a specific DNA polymerase produced after infection by herpes simplex virus. Virology30, 154 (1966).

    PubMed  Google Scholar 

  13. Keir, H. M.: Virus-induced enzymes in mammalian cells infected with DNA viruses. In: Molecular Biology of Viruses, pp. 67–99. XVIII Symp. Soc. gen. Microbiol., Cambridge: Cambridge University Press, 1968.

    Google Scholar 

  14. Lineweaver, H., andD. Burk: The determination of enzyme dissociation constants. J. Amer. chem. Soc.56, 408 (1934).

    Google Scholar 

  15. Loeb, L. A.: Purification and properties of deoxyribonucleic acid polymerase from nuclei of sea urchin embryos. J. biol. Chem.244, 1672 (1969).

    PubMed  Google Scholar 

  16. Lowry, O. H., N. J. Rosebrough, A. L. Farr, andR. J. Randall: Protein measurement with the Folin Phenol reagent. J. biol. Chem.193, 265 (1951).

    PubMed  Google Scholar 

  17. Mantsavinos, R.: Studies on the synthesis of deoxyribonucleic acid by mammalian enzymes. J. biol. Chem.239, 3431 (1964).

    PubMed  Google Scholar 

  18. Müller, W. E. G., Z. Yamazaki, H. H. Sögtrop, andR. K. Zahn: Action of 1-β-D-arabinofuranosylcytosine on mammalian tumor cells. Europ. J. Cancer8, 421 (1972).

    Google Scholar 

  19. Müller, W. E. G., D. Falke, B. Heicke, andR. K. Zahn: Biological activity of 2-phenylethanol and its derivatives. VIII. Influence on herpesvirus DNA-synthesis in rabbit kidney cells. Arch. ges. Virusforsch.40, 205 (1973).

    PubMed  Google Scholar 

  20. Skoog, L., andB. Nordenskjöld: Effects of hydroxyurea and 1-β-D-arabinofuranosyl-cytosine on deoxyribonucleotide pools in mouse embryo cells. Europ. J. Biochem.19, 81 (1971).

    PubMed  Google Scholar 

  21. Weissbach, A., S. L.Hong, J.Aucker, and R.Muller: Characterization of Herpes simplex virus-induced DNA polymerase (submitted).

  22. Zahn, R. K., E. Tiesler, A. K. Kleinschmidt undD. Lang: Ein Konservierungs- und Darstellungsverfahren für Desoxyribonucleinsäuren und ihre Ausgangsmaterialien. Biochem. Z.336, 281 (1962).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Müller, W.E.G., Falke, D. & Zahn, R.K. DNA-dependent DNA polymerase pattern in noninfected and herpesvirus infected rabbit kidney cells. Archiv f Virusforschung 42, 278–284 (1973). https://doi.org/10.1007/BF01265653

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01265653

Keywords

Navigation