Skip to main content
SpringerLink
Log in

Studies with divinyl ether-maleic anhydride and foot-and-mouth disease vaccines in swine

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

Mice treated with divinyl ether-maleic anhydride (DVE/MA) 7 days before, 2 days before, or simultaneously with foot-and-mouth disease (FMD) viral antigens (aqueous or oil emulsified) were more resistant to virus infection and released antibody earlier than mice treated with antigen alone. Simultaneous treatment of swine with these antigens plus DVE/MA resulted in a slightly enhanced early antibody response, which, in a test with oil-emulsified antigen, was not associated with an early induced antiviral resistance to FMD. In general, the primary and secondary antibody responses to oil antigen plus DVE/MA were the same as in control swine receiving the antigen alone. However, swine sensitized with aqueous antigen plus DVE/MA responded faster and developed higher antibody titers after a secondary treatment with aqueous antigen than swine treated similarly but without DVE/MA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Braun, W.: Influence of nucleic acid degradation products on antibody synthesis. In: Molecular and Cellular Basis of Antibody Formation (Sterzl, J., ed.), pp. 525 to 536. New York: Academic Press, 1965.

    Google Scholar 

  2. Braun, W., W. Regelson, Y. Yajima, andM. Ishizuka: Stimulation of antibody formation by pyran copolymer. Proc. Soc. exp. Biol. (N. Y.)133, 171–175 (1970).

    Google Scholar 

  3. Braun, W., Y. Yajima, L. Jimenez, andR. Winchurch: Activation, stimulation and the occasional non-specificity of antibody formation. In: Developmental Aspects of Antibody Formation and Structure (Stekzl, J., andI. Riha, eds.), pp. 799–815. New York: Academic Press, 1970.

    Google Scholar 

  4. `Campbell, C. H.: Influence of litter size, age variation, and selective breeding of mice on susceptibility to foot-and-mouth disease virus. Amer. J. vet. Res.29, 685–691 (1988).

    Google Scholar 

  5. Campbell, C. H., andJ. Y. Richmond: Enhancement, by two carboxylic acid interferon inducers, of resistance stimulated in mice by foot-and-mouth disease vaccine. Infect. Immunity7, 199–204 (1973).

    Google Scholar 

  6. Chester, T. J., E. DeClercq, andT. C. Merigan: Effect of separate and combined injections of poly rI. poly rC and endotoxin on reticuloendothelial activity, interferon, and antibody production in the mouse. Infect. Immun.3, 516–520 (1971).

    Google Scholar 

  7. Cone, R. E., andA. G. Johnson: Regulation of the immune system by synthetic polyribonucleotides. III. Action on antigen-reactive cells of thymic origin. J. exp. Med.133, 665–676 (1971).

    PubMed  Google Scholar 

  8. Diamantstein, T., H. Rühl, W. Vogt, andG. Bochert: Stimulation of B-cells by dextran sulphatein vitro. Immunology25, 743–747 (1973).

    PubMed  Google Scholar 

  9. Finney, D. J.: Probit analysis: a statistical treatment of the sigmoid response curve. London: Cambridge University Press, 1952.

    Google Scholar 

  10. Graves, J. H., P. D. McKercher, andJ. J. Callis: Foot-and-mouth disease vaccine: Influence of the vaccine virus subtype on neutralizing antibody and resistance to disease. Amer. J. vet. Res.33, 765–768 (1972).

    PubMed  Google Scholar 

  11. McKercher, P. D., andH. L. Bachrach: Purified foot-and-mouth disease virus vaccine: The significance of the dose of antigen in immunity. In: Proc. 2nd int. Congr. Virology (Budapest, 1971). Basel: S. Karger, 1972.

    Google Scholar 

  12. McKercher, P. D., andH. E. Farris, Jr.: Foot-and-mouth disease in swine: Response to inactivated vaccines. Arch. ges. Virusforsch.22, 451–461 (1967).

    PubMed  Google Scholar 

  13. McKercher, P. D., andR. A. Giordano: Foot-and-mouth disease in swine. I. The immune response of swine to chemically-treated and non-treated foot-and-mouth disease virus. Arch. ges. Virusforsch.20, 39–53 (1967).

    PubMed  Google Scholar 

  14. McVicar, J. W., J. Y. Richmond, C. H. Campbell, andL. D. Hamilton: Observations of cattle, goats and pigs after administration of synthetic interferon inducers and subsequent exposure to foot-and-mouth disease virus. Canad. J. comp. Med.37, 362–368 (1972).

    Google Scholar 

  15. Morahan, P. S., W. Regelson, andA. E. Munson: Pyran and polyribonucleotides: Differences in biological activities. Antimicrobiol. Agents and Chemother.2, 12–22 (1972).

    Google Scholar 

  16. Morgan, D. O., P. D. McKercher, andH. L. Bachrach: Quantisation of the antigenicity and immunogenicity of purified foot-and-mouth disease virus vaccines for swine and steers. Appl. Microbiol.20, 770–774 (1970).

    PubMed  Google Scholar 

  17. Munson, A. E., W. Regelson, W. Lawrence, andW. R. Wooles: Biphasic response of the reticuloendothelial system (RES) induced by pyran copolymer. J. reticuloendoth. Soc.7, 375–385 (1970).

    Google Scholar 

  18. Polatnick, J., andH. L. Bachrach: Production and purification of milligram amounts of foot-and-mouth disease virus from baby hamster kidney cell cultures. Appl. Microbiol.12, 368–373 (1964).

    PubMed  Google Scholar 

  19. Richmond, J. Y.: Mouse resistance against foot-and-mouth disease virus induced by injections of pyran. Infect. Immun.3, 249–253 (1970).

    Google Scholar 

  20. Richmond, J. Y., andC. H. Campbell: Influence of divinyl ether-maleic anhydride (pyran) on foot-and-mouth disease virus infection: Effects on adsorption and multiplication in mouse tissues. Arch. ges. Virusforsch.36, 232–239 (1971).

    Google Scholar 

  21. Richmond, J. Y., and C. H.Campbell: Enhancement of primary antigen specific resistance in infant mice with divinyl ether-maleic anhydride. Infect. Immun, (in press, 1974).

  22. Sellers, R. F., K. A. J. Herniman, andC. W. Hawkins: The effect of a synthetic anionic polymer (pyran) on the development of foot-and-mouth disease in guinea pigs, cattle and pigs. Res. Vet. Sci.13, 339–341 (1972).

    PubMed  Google Scholar 

  23. Wagner, G. G., J. L. Card, andK. M. Cowan: Immunochemical studies of foot- and-mouth disease. VII. Characterization of foot-and-mouth disease virus concentrated by polyethylene glycol precipitation. Arch. ges. Virusforsch.30, 343 to 352 (1970).

    Google Scholar 

Download references

Author information

Author notes

  1. C. H. Campbell

    Present address: Plum Island Animal Disease Center, Northeastern Region, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA

Authors and Affiliations

  1. Plum Island Animal Disease Center, Northeastern Region, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York, USA

    J. Y. Richmond & P. D. McKercher

Authors
  1. C. H. Campbell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Y. Richmond
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. D. McKercher
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Mention of a trademark or proprietary product does not constitute a guarantee or warranty of the product by the U.S. Department of Agriculture, and does not imply its approval to the exclusion of other products that may also be suitable.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Campbell, C.H., Richmond, J.Y. & McKercher, P.D. Studies with divinyl ether-maleic anhydride and foot-and-mouth disease vaccines in swine. Archiv f Virusforschung 46, 334–340 (1974). https://doi.org/10.1007/BF01240075

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01240075

Keywords

Search

Navigation