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Hamster endogenous retrovirus (HaER) — Distinct properties of structural proteins and DNA polymerase

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Summary

The structural proteins as well as some features of the RNA-dependent DNA polymerase of the hamster endogenous retrovirus (HaER) were examined. The polypeptide pattern of this virus is substantially different from that of other known retroviruses in containing major polypeptides with molecular weights of 68,000, 59,000, 27,000 and 24,000 daltons. Double antibody competitive radio-immunoassays showed that the HaER particles do not share any detectable antigenic relatedness with the murine viruses' p30, but manifest a considerable relatedness with the feline leukemia virus p27 and a slight cross-reactivity with the rat virus major protein. The RNA-dependent DNA polymerase of HaER virus has a molecular size of approximately 73,000 daltons and in contrast to other mammalian retroviruses shows no significant preference for Mn2+ over Mg2+. Apart from the lack of antigenic relatedness between the HaER virus proteins and the p30 protein of murine viruses, there is also no antigenic relatedness between HaER and murine viruses insofar as their DNA polymerase is concerned.

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Authors and Affiliations

  1. Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Anna Goldschmied-Reouven & A. Yaniv

  2. Department of Cell Biology and Histology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    A. Hizi

Authors
  1. Anna Goldschmied-Reouven
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  2. A. Yaniv
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  3. A. Hizi
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Goldschmied-Reouven, A., Yaniv, A. & Hizi, A. Hamster endogenous retrovirus (HaER) — Distinct properties of structural proteins and DNA polymerase. Archives of Virology 78, 245–253 (1983). https://doi.org/10.1007/BF01311319

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  • DOI: https://doi.org/10.1007/BF01311319

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