Skip to main content
Log in

Entry of adult T-cell leukemia-associated virus into human peripheral blood leukocytes

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

Within 10 minutes after tritium-labeled adult T-cell leukemia-associated virus (ATLV) inoculation, silver grains were found over human lymphocytes. At the time of entry of ATLV, the viral envelope was observed to fuse with the cell membrane.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Chosa, T., Yamamoto, N., Tanaka, Y., Koyanagi, Y., Hinuma, Y.: Infectivity dissociated from transforming activity in a human retrovirus, adult T-cell leukemia virus. Gann73, 844–847 (1982).

    Google Scholar 

  2. Dales, S., Hanafusa, H.: Penetration and intracellular release of the genomes of avian RNA tumor viruses. Virology50, 440–458 (1972).

    Google Scholar 

  3. Goto, T., Nakashima, H., Sano, K., Uyesaka, T., Nanya, H., Nakai, M.: A simple purification method of virus particles from cell culture. Med. Biol.105, 369–372 (1982).

    Google Scholar 

  4. Goto, T., Yuesaka, T., Sugita, K., Imura, S., Kojima, Y., Nakai, M.: Early events in murine leukemia virus infection by electron microscopy. In:Fatt, C. M. (ed.), Conference Proceedings of 3rd Asia Pacific Conference on Electron Microscopy, Singapore, 408–409, 1984.

  5. Hayami, M., Tsujimoto, H., Komuro, A., Hinuma, Y., Fujiwara, K.: Transmission of adult T-cell leukemia virus from lymphoid cells to non-lymphoid cells associated with cell membrane fusion. Gann75, 99–102 (1984).

    Google Scholar 

  6. Hinuma, Y., Nagata, K., Hanaoka, M., Nakai, M., Matsumoto, T., Kinoshita, K., Shirakawa, S., Miyoshi, I.: Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc. Natl. Acad. Sci. U.S.A.78, 6476–6480 (1981).

    Google Scholar 

  7. Hinuma, Y., Gotoh, Y., Sugamura, K., Nagata, K., Goto, T., Nakai, M., Kamada, N., Matsumoto, T., Kinoshita, K.: A retrovirus associated with human adult T-cell leukemia:In vitro activation. Gann73, 341–344 (1982).

    Google Scholar 

  8. Miyamoto, K., Gilden, R. V.: Electron miscrocopic studies of tumor viruses I. Entry of murine leukemia virus into mouse embryo fibroblasts. J. Virol.7, 395–406 (1971).

    Google Scholar 

  9. Miyoshi, I., Yoshimoto, S., Kubonishi, I., Shiraishi, Y., Ohtsuki, Y., Akagi, T.: Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukemic T-cell. Nature294, 770–771 (1981).

    Google Scholar 

  10. Nagy, K., Clapham, P., Cheingsong-Popov, R., Weiss, R. A.: Human T-cell leukemia virus type I: Induction of syncytia and inhibition by patients' sera. Int. J. Cancer32, 321–328 (1983).

    Google Scholar 

  11. Nakai, M., Goto, T., Miyoshi, H., Sano, K., Chosa, T., Hinuma, Y.: Reactivity of sera from patients with adult T-cell leukemia (ATL) with type C virus particles associated with ATL cell lines: Immunoelectron microscopic study. Gann73, 511–513 (1982).

    Google Scholar 

  12. Yuesaka, T.: Autoradiographic studies of early events in murine leukemia virus infection. J. Osaka Med. Coll.43, 17–28 (1984).

    Google Scholar 

  13. Yamamoto, N., Schneider, J., Hinuma, Y., Hunsmann, G.: Adult T-cell leukemia associated antigen (ATLA): detection of a glycoprotein in cell- and virus-free supernatant. Z. Naturforsch.37 c, 731–732 (1982).

    Google Scholar 

  14. Yoshida, M., Miyoshi, I., Hinuma, Y.: Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc. Natl. Acad. Sci. U.S.A.79, 2031–2035 (1982).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

With 3 Figures

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goto, T., Sugita, K., Imura, S. et al. Entry of adult T-cell leukemia-associated virus into human peripheral blood leukocytes. Archives of Virology 85, 321–328 (1985). https://doi.org/10.1007/BF01314241

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01314241

Keywords

Navigation