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[a]-Anellated carbazoles with antitumor activity: Synthesis and cytotoxicity

[a]-Anellierte Carbazole mit Antitumoraktivität: Synthese und Cytotoxizität

  • Organische Chemie Und Biochemie
  • Published:
Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary

The cycloadducts3,5, and7, readily available from methoxy-substituted 3-vinylindoles1 and2, were dehydrogenated withDDQ to the coplanar [a]-anellated carbazoles4,6, and8. Compound4a, also characterized by X-ray structural analysis, shows significant cytotoxicity against K562 und RXF393 human tumor cell lines.

Zusammenfassung

Die aus den methoxysubstituierten 3-Vinylindolen1 und2 zugänglichen Cycloaddukte3,5 und7 lassen sich mitDDQ zu den coplanar-anellierten Carbazolen4,6 und8 dehydrieren. Verbindung4a, die auch durch eine Röntǵenstrukturanalyse charakterisiert wurde, zeigt signifikante Cytotoxizität gegen Humantumor-Zellinien (K562 und RXF93).

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Authors and Affiliations

  1. Institut für Pharmazie, Universität Mainz, D-55099, Mainz, Germany

    M. Rogge, G. Fischer & U. Pindur

  2. Institut für Organische Chemie, Universität Mainz, D-55099, Mainz, Germany

    D. Schollmeyer

Authors
  1. M. Rogge
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  2. G. Fischer
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  3. U. Pindur
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  4. D. Schollmeyer
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Rogge, M., Fischer, G., Pindur, U. et al. [a]-Anellated carbazoles with antitumor activity: Synthesis and cytotoxicity. Monatsh Chem 127, 97–102 (1996). https://doi.org/10.1007/BF00807414

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  • DOI: https://doi.org/10.1007/BF00807414

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