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Role of zinc in blockade of excitotoxic action of quinolinic acid by picolinic acid

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Summary

This study examined whether picolinic acid (PIC) inhibits quinolinic acid (QUIN) — induced excitotoxicity through zinc chelation. Injection of QUIN into the nucleus basalis magnocellularis significantly depleted cortical choline acetyltransferase activity 7 days post injection and PIC inhibited this response. Zinc augmented the QUIN- but not NMDA-induced response. When PIC was co-administered with zinc, PIC failed to attenuate the QUIN-induced response. The inhibition of QUIN — induced cholinergic toxicity by PIC may involve chelation of zinc.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Queen's University, K 7L 3N6, Kingston, Ontario, Canada

    K. H. Jhamandas, R. J. Boegman & S. Flesher

  2. Department of Psychology and Psychiatry, Queen's University, Kingston, Ontario, Canada

    R. J. Beninger

Authors
  1. K. H. Jhamandas
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  2. R. J. Boegman
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  3. R. J. Beninger
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  4. S. Flesher
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Jhamandas, K.H., Boegman, R.J., Beninger, R.J. et al. Role of zinc in blockade of excitotoxic action of quinolinic acid by picolinic acid. Amino Acids 14, 257–261 (1998). https://doi.org/10.1007/BF01345272

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  • DOI: https://doi.org/10.1007/BF01345272

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