Summary
Plasma catecholamines and circulation parameters were studied in a patient with a Shy-Drager syndrome. Basal values of free noradrenaline and dopamine were within the normal range, whereas the adrenaline level was decreased. The response of plasma catecholamines to different kinds of physical activity was pathological. The inability to maintain elevated catecholamine levels during prolonged activity corresponded to impaired circulatory regulation and may provide an additional tool for diagnosis and monitoring of the Shy-Drager syndrome.
Zusammenfassung
Bei einer Patientin mit Shy-Drager-Syndrom wurden Plasmakatecholamine und Kreislaufparameter untersucht. Die basalen Werte an freiem Noradrenalin und Dopamin waren im Normbereich, Adrenalin erniedrigt. Die Reaktion der Plasmakatecholamine auf verschiedene Arten körperlicher Belastung war deutlich pathologisch. Die Unfähigkeit, die Plasmakatecholamine vor allem während längerer Aktivität auf erhöhtem Niveau zu halten, entsprach der beeinträchtigten Kreislaufregulation und kann als weiteres diagnostisches Kriterium angesehen werden.
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Gross, G., Nagel-Hiemke, M. & Krause, K.H. Plasma catecholamines during activation of the sympathetic nervous system in a patient with shy-drager syndrome. J. Neurol. 224, 125–131 (1980). https://doi.org/10.1007/BF00313350
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DOI: https://doi.org/10.1007/BF00313350