Summary
Plasma arginine vasopressin concentrations were determined by radio-immunoassay in 112 adult epileptics who were taking carbamazepine, phenytoin, primidone, or sodium valproate in long-term monotherapy, and in 19 controls. No significant difference was found between the groups, but some epileptics taking carbamazepine and primidone showed low values. Serum concentrations of carbamazepine did not correlate with the concentrations of plasma arginine vasopressin. In conclusion, there was no evidence of a stimulating effect of chronic carbamazepine medication or a special inhibiting effect of phenytoin on the release of vasopressin arginine from the posterior pituitary.
Zusammenfassung
Bei 112 unter Monotherapie mit Carbamazepin, Phenytoin, Primidon oder Valproat stehenden erwachsenen Anfallskranken sowie bei 19 gleichaltrigen Kontrollpersonen wurden radioimmunologisch die Vasopressin-Plasma-Konzentrationen bestimmt. Es wurden keine signifikanten Unterschiede zwischen den Gruppen gefunden. Einige der mit Carbamazepin und Primidon monotherapierten Epileptiker wiesen niedrige Vasopressin-Werte auf. Die Carbamazepin-Serumspiegel korrelierten nicht mit den Vasopressin-Konzentrationen. Somit ergab sich weder ein Hinweis auf eine vermehrte Vasopressin-Ausschüttung unter Langzeittherapie mit Carbamazepin noch eine besondere Hemmung der Ausschüttung durch Phenytoin.
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Krause, K.H., Rascher, W. & Berlit, P. Plasma arginine vasopressin concentrations in epileptics under monotherapy. J Neurol 230, 193–196 (1983). https://doi.org/10.1007/BF00313630
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DOI: https://doi.org/10.1007/BF00313630