Summary
Two cases of Addison's disease associated with myasthenia gravis are reported. This association has been described only rarely in the literature. In the first case, there were marked immunological abnormalities. It is most likely that the origin of the adrenocortical insufficiency in the second case is tuberculous. The pathogenetic mechanism of these associations is briefly discussed.
Similar content being viewed by others
References
Behan PO (1980) Immune disease and HLA associations with myasthenia gravis. J Neurol Neurosurg Psychiatry 43:611–621
Bosch EP, Reith PE, Cranner DK (1977) Myasthenia gravis and Schmidt syndrome. Neurology (Minneap) 27:1179–1180
Boulet P, Passouant P, Mirouze J, Bertrand A (1956) Myasthénie et insuffisance surrénale. Rev Neurol (Paris) 95:73–75
Cape CA (1972) Adrenal insufficiency in myasthenia gravis. Bull Los Angeles Neurol Soc 37:124–130
Engel AG (1979) Myasthenia gravis. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology. Disease of muscle, part II. North Holland, Amsterdam New York Oxford, pp 95–145
Kane CA, Weed L (1950) Myasthenia gravis associated with adrenocortical insufficiency. N Engl J Med 243:939–944
Lisak RP, Abdou NI, Zweiman B, Zmijewski C, Penn S (1976) Aspects of lymphocyte function in myasthenia gravis. Ann NY Acad Sci 274:402–410
Stuart Mason A, Meade TW, Lee JAH, Morris JN (1968) Epidemiological and clinical picture of Addison's disease. Lancet II:744–747
Weaver JA (1955) Changes induced in the thymus and lymph nodes of the rat by the administration of cortisone and sex hormones and other procedures. J Pathol Bacteriol 69:133–134
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dumas, P., Archambeaud-Mouveroux, F., Vallat, J.M. et al. Myasthenia gravis associated with adrenocortical insufficiency. J Neurol 232, 354–356 (1985). https://doi.org/10.1007/BF00313835
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00313835