Summary
Studies showed a significant decrease in the macrophage neutral protease and lymphocyte acid protease activities in patients with multiple sclerosis in remission, a significantly decreased neutral protease activity in macrophages in patients with myasthenia gravis and a significantly decreased acid protease activity in macrophages and lymphocytes in patients with polymyositis. No remarkable abnormalities were found in patients with myotonic dystrophy. These results suggest that multiple sclerosis, myasthenia gravis and polymyositis have an abnormality in immunological function.
References
Goto I, Shinno N, Kuroiwa Y (1983) Proteolytic enzyme activities in mononuclear cells and granulocytes of patients with various neurological disorders. J Neurol Sci 59:323–329
Kumagai K, Itoh K, Hinuma S, Tada M (1979) Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation. J Immunol Methods 29:17–25
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
McAdoo MH, Dannenberg AM Jr, Hayes CJ, James SP, Sanner JH (1973) Inhibition of the cathepsin D-type proteinase of macrophages by pepstatin, a specific pepsin inhibitor, and other substances. Infect Immunity 7:655–665
Paty DW, Kastrukoff L, Morgan N, Hiob L (1983) Suppressor Tlymphocytes in multiple sclerosis: analysis of patients with acute relapsing and chronic progressive disease. Ann Neurol 14:445–449
Rice GPA, Finney D, Braheny SL, Knobler RL, Sipe JC, Oldstone MBA (1984) Disease activity markers in multiple sclerosis. Another look at suppressor cells defined by monoclonal antibodies OKT 4, OKT 5, and OKT 8. J Neuroimmunol 6:75–84
Serra S, Grynbaum A, Lajtha A, Marks N (1972) Peptide hydrolases in spinal cord and brain of the rabbit. Brain Res 44:579–592
Weissmann G, Zurier RB, Spieler PJ, Goldstein IM (1971) Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. J Exp Med 134:149s-165s
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Goto, I., Shinno, N. & Kuroiwa, Y. Proteolytic enzyme activities of macrophages and lymphocytes in neurological diseases. J Neurol 233, 373–375 (1986). https://doi.org/10.1007/BF00313926
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DOI: https://doi.org/10.1007/BF00313926