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Fluctuations of interictal brain imaging in repeated 123I-IMP SPECT scans in an epileptic patient

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Summary

Single photon emission computed tomography (SPECT) brain scans with N-isopropyl-(iodine 123) p-iodoamphetamine (123I-IMP) were performed three times in interictal periods in a 35-year-old man with intractable frontal lobe epilepsy and normal X-ray CT findings. The first scan showed decreased 123I-IMP uptake in the right frontal lobe. This abnormal image was regarded as the primary focus of his epilepsy on the basis of its regional agreement with focal epileptic discharges on EEGs. In the second scan, he showed normal imaging, while the third scan showed the same abnormal image as before, in the right frontal lobe. The frequency of his clinical seizures was almost unchanged during the intervals between scans and further EEGs recorded soon after each scan showed almost no changes in the basic activities and frequency of the epileptic discharges. Such fluctuations in SPECT brain imaging suggest that the severity of functional inactivation underlying the focal hypoperfusion image as an epileptic focus may fluctuate considerably in the interictal state with no relation to the clinical features of epilepsy.

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References

  1. Bernardi S, Trimble MR, Frackowiak RSJ, Wise RJS, Jones T (1983) An interictal study of partial epilepsy using positron emission tomography and the oxygen-15 inhalation technique. J Neurol Neurosurg Psychiatry 46:473–477

    Google Scholar 

  2. Ell PJ, Lui D, Cullum I, Jarritt PH, Donaghy M, Harrison MJG (1983) Cerebral blood flow studies with 123iodine-labelled amines. Lancet I:1348–1352

    Google Scholar 

  3. Engel J (1983) Metabolic patterns of human epilepsy: clinical observations and possible physiological correlates. In: Baldy-Moulinier M, Ingvar DH, Meldrum BS (eds) Current problems in epilepsy. 1. Cerebral blood flow, metabolism and epilepsy. Libbey, London. pp 6–18

    Google Scholar 

  4. Engel J, Brown WJ, Kuhl DE, Phelps ME, Mazziotta JC, Crandall PH (1982) Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy. Ann Neurol 12:518–528

    Google Scholar 

  5. Hill TC, Holman BL, Lovett R, O'Leary DH, Front D, Magistretti P, Zimmerman RE, Moore S, Clouse M, Wu JL, Lin TH, Baldwin RM (1982) Initial experience with SPECT (single photon computerized tomography) of the brain using N-isopropyl I-123 p-iodoamphetamine: concise communication. J Nucl Med 23:191–195

    Google Scholar 

  6. Holman BL, Hill TC, Magistretti PL (1982) Brain imaging with emission computerized tomography and radiolabeled amines. Invest Radiol 17:206–215

    Google Scholar 

  7. Lang W, Podreka I, Suess E, Muller C, Zeitlhofer J, Deecke L (1988) Single photon emission computerized tomography during and between seizures. J Neurol 235:277–284

    Google Scholar 

  8. Lavy S, Melamed E, Portnoy Z, Carmon A (1976) Interictal regional cerebral blood flow in patients with partial seizures. Neurology 26:418–422

    Google Scholar 

  9. Lee BI, Markand ON, Siddiqui AR, Park HM, Mock B, Wellman HH, Worth RM, Edwards MK (1986) Single photon emission computed tomography (SPECT) brain imaging using N,N,N′-trimethyl-N′-(2 hydroxy-3-methyl-5-123I-iodobenzyl)-1,3-propanediamine 2 HCL (HIPDM): intractable complex partial seizures. Neurology 36:1471–1477

    Google Scholar 

  10. Magistretti PL, Uren RF (1983) Cerebral blood flow patterns in epilepsy. In: Nistico G, Perri RD, Meinardi H (eds) Epilepsy: an update on research and therapy. Liss, New York, pp 241–247

    Google Scholar 

  11. Robert GL, Lee MD, Hill TC, Holman BL, Clouse ME (1982) N-isopropyl (I-123) p-iodoamphetamine brain scans with single photon emission tomography: discordance with transmission computed tomography. Radiology 145:795–799

    Google Scholar 

  12. Sanabria E, Chauvel P, Askienazy S, Vignal JP, Trottier S, Chodkiewicz JP, Bancaud J (1983) Single photon emission computed tomography (SPECT) using 123I-isopropyl-iodo-amphetamine (IAMP) in partial epilepsy. In: Baldy-Moulinier M, Ingvar DH, Meldrum BS (eds) Current problems in epilepsy. 1. Cerebral blood flow, metabolism and epilepsy. Libbey, London, pp 82–87

    Google Scholar 

  13. Stefan H, Kuhnen C, Biersack HJ, Reichmann K (1987) Initial experience with 99m Tc-hexamethyl-propylene amine oxime (HM-PAO) single photon emission computed tomography (SPECT) in patients with focal epilepsy. Epilepsy Res 1:134–138

    Google Scholar 

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Authors and Affiliations

  1. Department of Neuropsychiatry, Kanazawa University School of Medicine, 13-1 Takaramachi, 920, Kanazawa, Japan

    I. Jibiki & N. Yamaguchi

  2. Departments of Nuclear Medicine, Kanazawa University School of Medicine, Kanazawa, Japan

    H. Matsuda & K. Hisada

Authors
  1. I. Jibiki
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  2. N. Yamaguchi
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  3. H. Matsuda
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  4. K. Hisada
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Jibiki, I., Yamaguchi, N., Matsuda, H. et al. Fluctuations of interictal brain imaging in repeated 123I-IMP SPECT scans in an epileptic patient. J Neurol 237, 372–375 (1990). https://doi.org/10.1007/BF00315662

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  • DOI: https://doi.org/10.1007/BF00315662

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