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Gas chromatographic determination of parabens in various pharmaceutical dosage forms

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Summary

A specific, sensitive and general applicabla gas chromatographic method is described for the determination of parabens in various liquid pharmaceutical preparations: propylparaben and butylparaben in a liquid antacid dosage form (I); methylparaben, ethylparaben and propylparaben in a syrup (II); methylparaben and propylparaben in a solution for injection (III). Each time one of the parabens is used as internal standard. The parabens are extracted with diethylether and derivatized by silylation. Different columns are used for the analysis of the parabens: 3% SE-30 column, a 3% QF-1 column for different selectivity, a 2% OV-1 column for isothermal operation.

Special attention is attributed to the standard: the parabens are dissolved in a minimal amount of 0.1 M sodium hydroxide and extracted in the same way as the pharmaceutical dosage form.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry and Drug Quality Control, State University of Ghent, Harelbekestraat 72, B-9000, Gent, Belgium

    F. De Croo, J. de Schutter, W. Van den Bossche & P. De Moerloose

Authors
  1. F. De Croo
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  2. J. de Schutter
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  3. W. Van den Bossche
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  4. P. De Moerloose
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De Croo, F., de Schutter, J., Van den Bossche, W. et al. Gas chromatographic determination of parabens in various pharmaceutical dosage forms. Chromatographia 18, 260–264 (1984). https://doi.org/10.1007/BF02270561

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  • DOI: https://doi.org/10.1007/BF02270561

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