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On-line solid-phase extraction-gas chromatography-ion trap tandem mass spectrometric detection for the nanogram per liter analysis of trace pollutants in aqueous samples

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Summary

On-line solid-phase extraction-gas chromatographyion-trap tandem mass spectrometry (SPE-GC-MS/MS) has been used for the trace-level determination of polar and apolar pesticides. The SPE-GC interface, an Autoloop 2000, was operated at an injection temperature of 90°C which permitted the determination of thermolabile pesticides such as carbofuran and carbaryl. Rectilinear calibration curves were obtained for the analytes tested over a range of 0.1–500 ng L−1, using a sample volume of 10–100 mL for enrichment on an SPE cartridge packed with styrene-divinylbenzene copolymer. The detection limits for the pesticides were in the 0.01–4 ng L−1 range. For a number of pesticides acceptable tandem mass spectra were obtained at levels as low as 0.1 ng L−1 level in real-life water samples.

As a demonstration of the applicability of this technique for inorganic anions, bromide and nitrite were converted into 4-bromoacetanilide and 2-phenylphenol, respectively. The reaction products were pooled and subjected to simultaneous analysis by the present method using full-scan mass spectrometric detection. The detection limits were 0.3 and 2 ng L−1, respectively.

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Author notes

  1. K. K. Verma & A. Jain

    Present address: Rani Durgavati University, Jabalpur, India

  2. A. J. H. Louter

    Present address: Novartis Pharma AG, Department of Technical Research and Development, Pharmaceutical Department, Building 360, room 916, P.O. Box 4002, Basel, Switzerland

Authors and Affiliations

  1. Department of Analytical Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081, HV Amsterdam, The Netherlands

    K. K. Verma, A. J. H. Louter, A. Jain, E. Pocurull, J. J. Vreuls & U. A. Th. Brinkman

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  1. K. K. Verma
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  2. A. J. H. Louter
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  5. J. J. Vreuls
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Verma, K.K., Louter, A.J.H., Jain, A. et al. On-line solid-phase extraction-gas chromatography-ion trap tandem mass spectrometric detection for the nanogram per liter analysis of trace pollutants in aqueous samples. Chromatographia 44, 372–380 (1997). https://doi.org/10.1007/BF02466313

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