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The tripeptide crystallizes as a zwitterion with a protonated histidyl ring and the C-terminus ionized and with five water molecules of hydration (C21H27N5O5.5H2O). The tripeptide adopts an all trans extended conformation with the histidine and phenyl rings parallel to one another. The C-terminus coils into a helical conformation. An intramolecular hydrogen bond between the C-terminus and the Nδ atom of the histidine ring stabilizes the helical conformation. The principal torsion angles are φ1 = −67.7 (8), ψ1 = 140.8 (5), ω1 = 171.0 (6), φ2 = −156.5 (5), ψ2 = 162.7 (5), ω2 = 175.0 (5), φ3 = −96.4 (6), ψT1 = 14.5 (8) and ψT2 = −164.6 (6)° [IUPAC-IUB Commission on Biochemical Nomenclature (1970). J. Mol. Biol. 52, 1–17]. The tripeptides are linked in infinite chains through a short intermolecular hydrogen bond between the C-terminal carboxylate group and the protonated histidyl N[epsilon] atom.

Supporting information

cif

Crystallographic Information File (CIF)
Contains datablocks global, Hip-L-His-L-Leu

fcf

Structure factor file (CIF format)
Supplementary material

CCDC reference: 126685

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