Elsevier

FEBS Letters

Volume 254, Issues 1–2, 28 August 1989, Pages 69-73
FEBS Letters

Calmodulin-independent bovine brain adenylate cyclase Amino acid sequence and nucleotide sequence of the corresponding cDNA

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Abstract

An individual catalytic component of calmodulin-independent adenylate cyclase has been isolated from bovine brain cortex. Affinity chromatography on an immunosorbent was used. The amino acid sequence of adenylate cyclase as well as the corresponding nucleotide sequence of the cDNA has been determined. cDNA of adenylate cyclase encodes a protein consisting of 834 amino acid residues and the signal peptide (19 amino acid residues). A series of adenylate cyclase isoforms has been found. A homology between adenylate cyclases from bovine brain, E. coli and Bordetella pertussis has been revealed.

Keywords

Adenylate cyclase
Monoclonal antibody
Amino acid sequence
cDNA cloning
Nucleotide sequence

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