Elsevier

FEBS Letters

Volume 283, Issue 2, 3 June 1991, Pages 199-202
FEBS Letters

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11

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Abstract

A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open reading frame coding for an AGIF precursor of 199 amino acids. Analysis of the sequence of this cDNA revealed identity of this factor with a recently reported novel cytokine, designated interleukin-11 (IL-11). AGIF/IL-11 may play an important role in stromal cell-associated hematopoiesis through its regulatory action on adipocyte differentiation in the bone marrow microenvironment.

Keywords

Adipogenesis inhibitory factor
Interleukin-II
cDNA cloning
Bone marrow stromal cell

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