Further ineupatorolide-like germacranolides from Inula cuspidata

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Abstract

The aerial parts of Inula cuspidata afforded in addition to known compounds five germacranolides closely related to ineupatorolide A. Furthermore,

References (8)

  • F. Bohlmann et al.

    Phytochemistry

    (1981)
  • F. Bohlmann et al.

    Phytochemistry

    (1979)
  • N.H. Fischer et al.

    Fortschr. Chem. Org. Naturst.

    (1979)
  • R.N. Baruah et al.

    J. Org. Chem.

    (1980)
There are more references available in the full text version of this article.

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    Compound 13 is the first germacrane sesquiterpene to have been obtained from A. annua. This germacrane allylic hydroxide has been reported as a natural product from various other species on several occasions (Fattorusso et al., 1978; Bohlman et al., 1982; Nagashima et al., 1990) and its isolation from the seeds of A. annua may have some relevance to the biogenesis of all of the eudesmanes 7–12, as is discussed below. After making complete NMR spectroscopic assignments for the germacrane 13 by 2D NMR (presented for the first time in Tables 1 and 2) it was possible to make a detailed interpretation of correlations appearing in the NOESY spectrum of this compound, which in turn have demonstrated that 13 exists in solution predominantly as the conformer shown in Fig. 4 (cf. other recent studies of the conformation of the 10-membered germacrane ring; Barrero et al., 1999; Wong and Brown, 2002b).

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Part 379 in the series “Naturally Occurring Terpene Derivatives”. For Part 378 see Bohlmann, F. and Zdero, C. (1982) Phytochemistry 21, (in press).

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