Elsevier

Phytochemistry

Volume 31, Issue 9, September 1992, Pages 2999-3001
Phytochemistry

Usnic acid amide, a phytotoxin and antifungal agent from Cercosporidium henningsii

https://doi.org/10.1016/0031-9422(92)83434-ZGet rights and content

Abstract

Usnic acid amide, a phytotoxin related to (−)-usnic acid and (−)-cercosporamide, has been isolated from the cassava fungal pathogen Cercosporidium henningsii. Usnic acid amide also shows moderate antifungal activity and inhibiton of protein kinase C.

References (6)

  • S. Huneck et al.

    Tetrahedron Letters

    (1981)
  • W.R. Bishop et al.

    Biochem. Pharmacol.

    (1990)
  • F. Sugawara et al.

    J. Org. Chem.

    (1991)
There are more references available in the full text version of this article.

Cited by (27)

  • Allelopathy and allelochemicals from microalgae: An innovative source for bio-herbicidal compounds and biocontrol research

    2021, Algal Research
    Citation Excerpt :

    This mechanism is similar to commercial herbicides in the triketone family. But although the combination of microalgae and lichen fungus provides the necessary context for the production of usnic acid, it can also be assumed that a significant part of this baggage comes mainly from the symbiotic fungus, since usnic acid derivatives are produced by fungi [190–192]. From a general point of view, studies on these mechanisms of action suggest an open space for research and discovery of new metabolites with herbicidal potential.

  • Bioprospecting of endophytic fungi for antibacterial and antifungal activities

    2021, Phytomedicine: A Treasure of Pharmacologically Active Products from Plants
  • Lichen as nature’s basket full of bioactive compounds

    2020, New and Future Developments in Microbial Biotechnology and Bioengineering: Recent Advances in Application of Fungi and Fungal Metabolites: Current Aspects
  • Discovery of novel (+)-Usnic acid derivatives as potential anti-leukemia agents with pan-Pim kinases inhibitory activity

    2019, Bioorganic Chemistry
    Citation Excerpt :

    +)-UA (1) gets more attention than (-)-UA (2) as it exhibits greater potency and a wider range of biological activities including antibiotic, antiviral, anti-inflammatory and anti-proliferative activities [3,4]. UA contains a unique dibenzofuran scaffold, which is rare but could be seen in other natural products like (-)-Cercosporamide (3) [5], UA amide (4) [6] as well as synthetic active compounds CGS-34043 (5) [7], as shown in Fig. 1. Cercosporamide, similar to UA in scaffold, was recently reported as a novel MNK1/2 kinase inhibitor with both in vitro and in vivo activity [5].

View all citing articles on Scopus
View full text