Usnic acid amide, a phytotoxin and antifungal agent from Cercosporidium henningsii
References (6)
- et al.
Tetrahedron Letters
(1981) - et al.
Biochem. Pharmacol.
(1990) - et al.
J. Org. Chem.
(1991)
Cited by (27)
Dibenzofurans from nature: Biosynthesis, structural diversity, sources, and bioactivities
2024, Bioorganic ChemistryThe usnic acid derivative peziculone targets cell walls of Gram-positive bacteria revealed by high-throughput CRISPRi-seq analysis
2023, International Journal of Antimicrobial AgentsAllelopathy and allelochemicals from microalgae: An innovative source for bio-herbicidal compounds and biocontrol research
2021, Algal ResearchCitation Excerpt :This mechanism is similar to commercial herbicides in the triketone family. But although the combination of microalgae and lichen fungus provides the necessary context for the production of usnic acid, it can also be assumed that a significant part of this baggage comes mainly from the symbiotic fungus, since usnic acid derivatives are produced by fungi [190–192]. From a general point of view, studies on these mechanisms of action suggest an open space for research and discovery of new metabolites with herbicidal potential.
Bioprospecting of endophytic fungi for antibacterial and antifungal activities
2021, Phytomedicine: A Treasure of Pharmacologically Active Products from PlantsLichen as nature’s basket full of bioactive compounds
2020, New and Future Developments in Microbial Biotechnology and Bioengineering: Recent Advances in Application of Fungi and Fungal Metabolites: Current AspectsDiscovery of novel (+)-Usnic acid derivatives as potential anti-leukemia agents with pan-Pim kinases inhibitory activity
2019, Bioorganic ChemistryCitation Excerpt :+)-UA (1) gets more attention than (-)-UA (2) as it exhibits greater potency and a wider range of biological activities including antibiotic, antiviral, anti-inflammatory and anti-proliferative activities [3,4]. UA contains a unique dibenzofuran scaffold, which is rare but could be seen in other natural products like (-)-Cercosporamide (3) [5], UA amide (4) [6] as well as synthetic active compounds CGS-34043 (5) [7], as shown in Fig. 1. Cercosporamide, similar to UA in scaffold, was recently reported as a novel MNK1/2 kinase inhibitor with both in vitro and in vivo activity [5].