Total synthesis and absolute stereochemistry of the antifungal dipeptide Sch 37137 and its 2S,3S - isomer
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FTIR spectra and conformational structure of deutero-β-alanine isolated in argon matrices
2016, Journal of Molecular SpectroscopyCitation Excerpt :Elucidation of the molecular structure of non-ionized β-alanine is important for two reasons. First, β-alanine is the only naturally occurring β-amino acid with a significant biological [1–4] and pharmacological [5–7] importance related to its being a part of natural or synthesized peptides. Inclusion of a β-amino acid in a peptide results in appearance of an additional rotational degree of freedom (one more single CC bond) which increases the flexibility of the peptide backbone.
UV-induced isomerization of β-alanine isolated in argon matrices
2012, Journal of Molecular StructureCitation Excerpt :β-Alanine is present in some naturally occurring peptides with important pharmacological properties [4–6]. Peptides, in which an α-amino-acid residue was replaced by a β-amino acid residue in the peptide sequence, have shown increased stability against certain peptidases [7–11]. As other amino acids, β-alanine in solid state or in aqueous solutions exists in the bipolar (zwitterion) form [12], but in the gas phase it is present in the neutral form.
Efficient synthesis of orthogonally protected anti-2,3-diamino acids
2005, TetrahedronEfficient asymmetric synthesis of 2,3-diamino-3-phenylpropanoic acid derivatives
2001, TetrahedronCitation Excerpt :The 2,3-diamino acid family constitutes a key structural component in a variety of antibiotics1 and anti-fungal dipeptides2 as well as in other biologically active molecules.3
An all-anti conformation of the β-Ala moiety in the crystalline state
1999, Tetrahedron LettersA simple and practical access to enantiopure 2,3-diamino acid derivatives
1999, Tetrahedron Asymmetry