Elsevier

Tetrahedron Letters

Volume 35, Issue 18, 2 May 1994, Pages 2941-2944
Tetrahedron Letters

Synthesis of dinucleoside phosphoramidimidates

https://doi.org/10.1016/S0040-4039(00)76666-4Get rights and content

Abstract

The first nucleoside derivatives of phosphoramidimidic acid are described. A series of thymidine dinucleoside phosphoramidimidates 1f–i with substituted phenyl groups were synthesized and their stability in organic and aqueous media evaluated.

The synthesis of a series of nucleoside derivatives of phosphoramidimidic acid is described.

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References (16)

  • E. Uhlman et al.

    Chem. Rev

    (1990)
    F. Eckstein
    (1991)
  • P.O.P. T'so et al.

    Ann. New York Academy of Sciences

    (1987)
  • J.S. Cohen
    (1989)
    C.A. Stein et al.

    Pharmacol Ther

    (1991)
  • W.K.-D. Brill et al.

    Tetrahedron Lett.

    (1988)
    K. Bjerg»rde et al.

    Nucleic Acids Res

    (1991)
    W.S. Marshall et al.

    Science

    (1993)
  • F. Eckstein

    Annu. Rev. Biochem.

    (1985)
  • A. Jager et al.

    Biochemistry

    (1988)
  • V.A. Gilyarov et al.

    J. Gen. Chem. USSR

    (1966)
    E.E. Nifantev et al.

    J. Gen. Chem. USSR

    (1971)
    G.K. Genkina et al.

    J. Gen. Chem. USSR

    (1971)
    G.K. Genkina et al.

    J. Gen. Chem. USSR

    (1969)
    M.I. Kabachnik et al.

    J. Gen. Chem. USSR

    (1982)
There are more references available in the full text version of this article.

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