Penems containing amino acid derived substituents at C-2
Several penems of types I – IV containing side-chains at C-2 derived from D- or L-amino acids were synthesized. The in-vitro antibacterial spectrum of these compounds is influenced by the stereochemistry of the side-chain. In general, penems with side-chains derived from D-amino acids are most potent, particularly against gram-negative organisms, relative to the isomeric analogs.
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