Examination of the sialyl lewis X - calcium complex by electrospray mass spectrometry

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Abstract

The Ca2+ binding properties of the cell-surface carbohydrate sialyl Lewis x, SLex, and its 2-, 3-, and 4- deoxygenated-fucose analogs, were examined by pneumatically-assisted electrospray (ion spray) mass spectrometry. Computer-assisted modeling and mass spectral evidence suggest that Ca2+ is coordinated primarily to the GalGlcNAc moeity of SLex.

The Ca2+binding properties of the carbohydrate sialyl Lewis X were examined by electrospray mass spectrometry.

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