Dual antagonists of platelet activating factor and histamine. 2. pyridine ring substitution of N-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidines☆
The syntheses and biological activities of pyridine ring substituted analogs of Sch 37370, a dual antagonist of PAF and histamine, are described.
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Synthetic transformations mediated by the combination of titanium(IV) alkoxides and Grignard reagents: selectivity issues and recent applications. Part 2: Reactions of alkenes, allenes and alkynes
2010, TetrahedronCitation Excerpt :In contrast to the corresponding four- and five-membered ring products, the six- and seven-membered bis-conjugated allenes formed from tethered bis(propargylic) alcohol derivatives are not isolated, since they undergo electrocyclisation to give bicyclic cyclobutene compounds 50 (Scheme 103).217 Finally, and as already mentioned, related intramolecular alkyne–allene coupling reactions starting from allenynes (1,2-dien-6-ynes and 1,2-dien-7-ynes) have been described as well.202–204 Titanacyclopropanes generated from Ti(Oi-Pr)4 and a Grignard reagent react with alkynes with a suitable leaving group at the propargylic position to give allenyltitanium complexes O1 that are in equilibrium with the corresponding propargyl–titanium complexes O2 via a metallotropic shift (Scheme 104).238
Analogues of 1-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1, 2-b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase
1999, Bioorganic and Medicinal ChemistryAnalogs of 4-(3-bromo-8-methyl-10-methoxy-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(4-pyridinylacetyl)piperidine N- oxide as inhibitors of farnesyl protein transferase
1999, Bioorganic and Medicinal Chemistry LettersConformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine
1999, Bioorganic and Medicinal ChemistryDual antagonists of platelet activating factor and histamine. Part 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines
1998, Bioorganic and Medicinal Chemistry LettersSynthesis of isomeric 3-piperidinyl and 3-pyrrolidinyl benzo[5,6]cyclohepta[1,2-b]pyridines: Sulfonamido derivatives as inhibitors of Ras prenylation
1998, Bioorganic and Medicinal Chemistry
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A preliminary account of this work was presented at the 204th National Meeting of American Chemical Society, Division of Organic Chemistry, Washington, D.C., August 1992; ORG 298. For the previous paper in this series see reference 8a.