The synthesis of 2,2,24- trisubstituted oxetanes as new azole antifungal agents

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Abstract

Synthesis and biological activities of cis- and trans- 2,2,4 - trisubstituted oxetanes 4 and 5 are described. The key diol intermediates 9 and 10 exhibited exceptionally good in vitro and in vivo antifungal activity.

Synthesis and biological activities of cis- and trans- 2,2,4-trisubstituted oxetanes are described. The key diol intermediates exhibited exceptionally good in vitro and in vivo antifungal activity.

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