Biochemical and Biophysical Research Communications
Bay K 8644, a voltage-sensitive calcium channel agonist, facilitates secretion of atrial natriuretic polypeptide from isolated perfused rat hearts
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Cited by (56)
Different subcellular populations of L-type Ca <sup>2+</sup> channels exhibit unique regulation and functional roles in cardiomyocytes
2012, Journal of Molecular and Cellular CardiologyCitation Excerpt :However, the precise role of ICa,L remains unclear. Some studies have shown that ICa,L stimulates ANP release, but other studies have suggested that ICa,L inhibits ANP secretion [105–112]. ANP release is also largely controlled by mechanical stretch, and ICa,L is coupled to the regulation of stretch-induced ANP secretion, suggesting there may be different roles for Ca2+ in basal versus stimulated release [112–114].
Stretch-activated non-selective cation channel: A causal link between mechanical stretch and atrial natriuretic peptide secretion
2008, Progress in Biophysics and Molecular BiologyCitation Excerpt :Surprisingly, Ni2+, an effective inhibitor of the Na+–Ca2+ exchanger, greatly attenuated extracellular Na+ depletion-induced intracellular Ca2+ increase but not ANP secretion (Seul et al., 2003). In fact, the role of intracellular Ca2+ in ANP secretion is controversial: an increase of ANP secretion by increasing intracellular Ca2+ and by decreasing intracellular Ca2+ has both been proposed (Ito et al., 1988; Saito et al., 1986; Schiebinger, 1989; de Bold and de Bold, 1989; Matsubara et al., 1988). The reason behind this discrepancy is not clear yet.
Identification, localization and interaction of SNARE proteins in atrial cardiac myocytes
2006, Journal of Molecular and Cellular CardiologyCitation Excerpt :Whereas increases in Ca2+ have been demonstrated to evoke exocytosis in a number of secretory cell types, there is no clear consensus regarding a role for Ca2+ in ANP secretion. Studies using perfused rat heart or isolated atria have reported that Ca2+ has a positive role [41,42], no involvement or even a negative role in ANP release [13,43,44]. For example, ANP release was shown to be amplified by the Ca2+ channel agonist Bay K8644 in paced rat atria [45] but not effective at modulating release from quiescent atria or myocyte cultures, suggesting that basal and or stimulated release are differentially regulated [46,47].
Attenuation of negatively regulated ANP secretion by calcium in hypertrophied atria
2002, Regulatory Peptides