Erythroid differentiation factor can modulate follicular granulosa cell functions
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Activin
2021, Handbook of Hormones: Comparative Endocrinology for Basic and Clinical ResearchActivin
2015, Handbook of Hormones: Comparative Endocrinology for Basic and Clinical ResearchEffect of activin A and inhibin A on expression of the inhibin/activin β-B-subunit and gonadotropin receptors in granulosa cells of the hen
2006, General and Comparative EndocrinologySynergistic effects of activin and FSH on hyperphosphorylation of Rb and G1/S transition in rat primary granulosa cells
2003, Molecular and Cellular EndocrinologyBiological Function and Cellular Mechanism of Bone Morphogenetic Protein-6 in the Ovary
2001, Journal of Biological ChemistryCitation Excerpt :Experiments in which BMP-6 was added to cultured GCs indicated that BMP-6 is potent in suppressing FSH-induced P4 production without affecting FSH-induced E2 production and that BMP-6 does not exhibit any mitogenic activity in GCs. Our data demonstrate that the biological effects of BMP-6 on GCs are distinct from those of other TGF-β superfamily members, including inhibin (36, 37), activin (37-39), TGF-β (36,40-43), BMP-4 (28), BMP-7 (28), and GDF-9 (14). However, it is intriguing that the function of BMP-6 with respect to GC steroidogenesis has a strong resemblance to that of BMP-15, another oocyte-secreted factor (16).
Bone morphogenetic protein-15: Identification of target cells and biological functions
2000, Journal of Biological ChemistryCitation Excerpt :Because human ooctyes express BMP-15 (8), it will be interesting to determine whether these principles apply to women. It is noteworthy that the effects of BMP-15 on GCs are different from those of other members of the TGF-β superfamily, including inhibin (16, 17), activin (17-19), TGF-β (16, 20-23), BMP-4 (15), BMP-7 (15), and GDF-9 (24). As such, it would appear that the biological activity of BMP-15 in the GC is unique.