123I research and production at Brookhaven National Laboratory

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Abstract

The procedures for preparing high purity 123I at the Brookhaven Linac Isotope Producer using the 127I(p, 5n)123Xe reaction on a NaI target are described. The activity is supplied in a glass ampoule with anhydrous 123I deposited on the interior walls, allowing maximum flexibility in subsequent iodinations. Preliminary experience with a continuous flow target is also described. The results of a series of measurements of specific activity by neutron activation, x-ray fluorescence, u.v. absorption, and wet chemistry generally showed no detectable carrier. HPLC methods to analyze the chemical form of radioiodine and to characterize various iodinated radiopharmaceuticals have been developed. These methods provide higher sensitivity, speed and resolution than commonly used techniques.

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