Calcium resorption from bone in a human studied by 41Ca tracing
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Cited by (36)
A New capability for <sup>41</sup>Ca analysis using CaF<inf>3</inf><sup>-</sup> at the Xi'an-AMS
2019, Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and AtomsEfficient <sup>41</sup>Ca measurements for biomedical applications
2015, Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and AtomsA Bayesian approach to an interlaboratory comparison
2015, Chemometrics and Intelligent Laboratory SystemsCitation Excerpt :For biomedical studies, the low detection limit and the long half-life mean that a single, safe dose can be given to an animal or a human subject, and then research can be conducted for the biological lifetime of the subject without another dose ever being administered [13]. In the 1990's it was suggested that 41Ca could be used as a tracer to elucidate calcium metabolism in humans [14,15], and this has now emerged as the most important application of this nuclide [16–19]. For example, clinical trials have studied the efficacy of both commercial anti-osteoporosis drugs and of botanical treatments [6,7].
Calcium isolation from large-volume human urine samples for <sup>41</sup>Ca analysis by accelerator mass spectrometry
2013, Applied Radiation and IsotopesCitation Excerpt :An extremely rare isotope of calcium, 41Ca is an effective tool to track calcium release from bone (Denk et al., 2006, 2007; Elmore et al., 1990; Freeman et al., 1997; Johnson et al., 1994; Lee et al., 2011).
Ultra-trace analysis of <sup>41</sup>Ca in urine by accelerator mass spectrometry: An inter-laboratory comparison
2013, Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and AtomsApplications of accelerator mass spectrometry
2013, International Journal of Mass SpectrometryCitation Excerpt :Since natural 26Al/27Al and 41Ca/40Ca isotope ratios are exceedingly small in humans, in the range of 10−14, and the half-lives are much longer than the one of 14C (Table 1), strong radionuclide signals can be administered to humans. Pioneering long-time experiments in humans have been performed for 26Al [147] and 41Ca [148], following the radionuclide concentrations over 5–4 orders of magnitude, respectively. Although some interesting implication for studies of osteoporosis were indicated in a 41Ca labeling experiment by Freeman et al. [149], followed up by another extensive study of Denk et al. [150], 41Ca has not yet entered the realm of drug developments.