Elsevier

Psychiatry Research

Volume 46, Issue 3, March 1993, Pages 261-267
Psychiatry Research

Possible association of c-harvey-ras-1 (HRAS-1) marker with autism

https://doi.org/10.1016/0165-1781(93)90094-WGet rights and content

Abstract

We tested for an association between autism and genes coding for enzymes involved in monoaminergic metabolism and for a linked marker, c- Harvey-Ras-1 (HRAS 1), using restriction fragment length polymorphisms. We did not find evidence of an association between autism and genes coding for tyrosine hydroxylase, dopamine-β-hydroxylase (DBH), and tryptophan hydroxylase. However, we report a positive association between autism and the locus containing the gene for HRAS-1.

References (29)

  • O. Brunet et al.

    Echelle de développement psychomoteur de la premiére enfance

  • D.E. Comings et al.

    The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders

    Journal of the American Medical Association

    (1991)
  • T. d'Amato et al.

    Two Taq I dimorphic sites at the human β-hydroxylase locus

    Nucleic Acids Research

    (1989)
  • J.A. Egeland et al.

    Bipolar affective disorder linked to DNA markers on chromosome 11

    Nature

    (1987)
  • Cited by (53)

    View all citing articles on Scopus

    Josiane Hérault, Ph.D., is Researcher in Biology; Anne Perrot, M.D., is Instructor in Psychiatry; Catherine Barthélémy, M.D., Ph.D., is Professor of Physiology; Matthias Büchler, M.D., is Resident in Medicine; Catherine Cherpi is Technical Assistant; Dominique Sauvage, M.D., is Professor of Child Psychiatry; Gilbert Lelord, M.D., Ph.D., is Professor of Physiology; and Jean-Pierre Müh, M.D., Ph.D., is Professor of Biochemistry, National Institute for Health and Medical Research, U 316 “The Nervous System From the Fetus to the Child,” CHRU Bretonneau, 37044 Tours Cedex, France. Marion Leboyer, M.D., is Chief Resident in Psychiatry, and Jacques Mallet, Ph.D., is Research Director, in UPR 23 of the National Center for Scientific Research, 91198 Gif-sur-Yvette, France.

    View full text