Biochemical and Biophysical Research Communications
Regular ArticleInhibition of c-myc Expression Induced by 4-Hydroxynonenal, a Product of Lipid Peroxidation, in the HL-60 Human Leukemic Cell Line
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Post-translational inhibition of YAP oncogene expression by 4-hydroxynonenal in bladder cancer cells
2019, Free Radical Biology and MedicineCitation Excerpt :After 48 h and 72 h the expression was similar to the control. These results are in agreement with our previous results obtained on other oncogenes, where it was demonstrated that a single treatment with 10 μM HNE significantly inhibited the expression of c-myc, c-myb and cyclins D1/D2 within 4–8 h, whereas after 24 h their expression increased up to the control values [29,32,33]. The reversibility of the inhibitory effect on gene expression displayed by HNE may be due to the short life of this aldehyde in the cell cultures [43].
On the role of 4-hydroxynonenal in health and disease
2015, Biochimica et Biophysica Acta - Molecular Basis of DiseaseHydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function
2012, Microvascular ResearchCitation Excerpt :Ox-PLs also induce expression of OKL 38 and ATF4 through transcription factor nuclear factor E2-related factor (Nrf2) mediated signal transduction (He et al., 2001). 4-HNE treatment of cells alters the expression of several transcription factors including c-Myc, c-Myb and c-Jun (Barrera et al., 1994; Barrera et al., 2005; Barrera et al., 1996), suggesting that it has more global effects on protein expression and cell function. Endothelial cells, lining the blood vessels, serve as a semi-permeable barrier to circulating cells, plasma albumin, macromolecules, and bioactive agents.
MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation
2009, Free Radical Biology and Medicine