Biochemical and Biophysical Research Communications
Mutagenicity of metronidazole: Activation by mammalian liver microsomes
References (18)
- et al.
Mutation Res
(1974) - et al.
Biochem. Pharmacol
(1974) - et al.
Biochem. Pharmacol
(1966) - et al.
Calif. Med
(1972) - et al.
Science
(1975) - et al.
- et al.
The Medical Letter on Drugs and Therapeutics
(1975)- et al.
J. Gen. Microbiol
(1970)
Cited by (219)
IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk
2015, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :Although the above discussion has focused on in vitro simulation of oxidative metabolism for the generation of mutagenic metabolites, many mutagens require other types of enzymatic reactions. For example, diazo compounds and nitroarenes require reductive metabolism to generate arylamine intermediates that can subsequently be converted to hydroxyarylamines via P450 1A2 [92–95]. Potent mutagens can be generated by reductive cleavage of benzidine-based diazo compounds, and metabolic activation mixtures containing FMN (flavin mononucleotide) and hepatic S9 from Golden Syrian Hamsters have been employed to improve detection of this class of mutagens [92].
Analytical methods in bioassay-directed investigations of mutagenicity of air particulate material
2007, Mutation Research - Reviews in Mutation ResearchSynthesis and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives and their Pd(II) complexes
2006, European Journal of Medicinal ChemistryCitation Excerpt :The drug of choice to treat amoebic dysentery is metronidazole, which is associated with serious side effects [5]. However, critical lateral effects have been described, i.e. neurological alterations produced by interaction of the drug with the central nervous system, the impairment of cardiac rhythm due to the chelation of MNZ with calcium ions [6–10]. It is carcinogenic to humans and animals [11].
3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells
2005, Bioorganic and Medicinal Chemistry LettersMutagens in surface waters: A review
2004, Mutation Research - Reviews in Mutation Research