Biochemical and Biophysical Research Communications
The elastogenic effect of recombinant transforming growth factor-beta on porcine aortic smooth muscle cells
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2017, Fetal and Neonatal Physiology, 2-Volume SetA cytokine axis regulates elastin formation and degradation
2013, Matrix BiologyCitation Excerpt :Overexpression of active TGFβ1 in experimental abdominal aortic aneurysms is associated with preservation of medial elastin (Dai et al., 2005). Indeed, numerous studies have established that TGFβ1 augments both tropoelastin mRNA abundance (Liu and Davidson, 1988; McGowan and McNamer, 1990; Kahari et al., 1992b; Zhang et al., 1995) and elastin formation (McGowan and McNamer, 1990; Katsuta et al., 2008). Mechanistically, TGFβ1 mediates these effects by modulating tropoelastin promoter activity, mRNA stability and elastin degradation.
Developmental Biology of the Pulmonary Vasculature
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2010, BiomaterialsCitation Excerpt :Thus, taking the foregoing findings together, DOXY may well be involved with the LOX enhancer. TGF-β1 and IGF-1 are powerful inducers of elastin expression [25,26,53,54], though there is no article describing that TGF-β1 and IGF-1 are increased by the presence of DOXY. In our study, although the mechanisms of TGF-β1 and IGF-1 up-regulation remain unclear, it seems very likely that they are involved in the maintenance of elastin in the aortic wall.
Diseases of Pulmonary Circulation
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