Occurrence of cholesterol 7α- and 7β-hydroperoxides in rat skin as aging markers
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Cited by (34)
Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides
2024, Free Radical Biology and MedicineAlcohol-induced Membrane Damage
2004, Comprehensive Handbook of Alcohol Related PathologyOxysterol stimulation of epidermal differentiation is mediated by liver X receptor-β in murine epidermis
2002, Journal of Investigative DermatologyCitation Excerpt :Cholesterol synthesis is very active in the epidermis and large quantities of cholesterol are required for the formation of lamellar bodies (Feingold, 1991). Stress to the epidermis such as ultraviolet light, air pollution, and aging increases the oxidative state of keratinocytes thereby potentially increasing the formation of oxysterols (Ozawa et al, 1991;Darr and Fridovich, 1994;Fuchs et al, 1995;Yamazaki et al, 1999). Moreover, cholesterol is converted to oxysterols, some of which are LXR ligands, by P450 enzymes that are expressed in many tissues, including the epidermis (Jugert et al, 1994;Russell, 2000).
Age-related changes in oxidative damage to lipids and DNA in rat skin
2001, Mechanisms of Ageing and DevelopmentRole of active oxygen species and antioxidants in photoaging
2001, Journal of Dermatological ScienceOxysterols induce differentiation in human keratinocytes and increase AP-1-dependent involucrin transcription
2000, Journal of Investigative DermatologyCitation Excerpt :For example, 27-cholesterol hydroxylase is a widely expressed enzyme that oxidizes cholesterol (Anderson et al. 1989), which we have shown to be expressed in the epidermis (unpublished observations). Moreover, stresses to the epidermis such as ultraviolet light and air pollution, and chronological aging, increase the oxidative state of keratinocytes, thereby leading to increased formation of oxysterols (Ozawa et al. 1991;Darr & Fridovich 1994;Fuchs et al. 1995). In tissues where it has been analyzed (liver, brain, adrenal) oxysterols are present in concentrations sufficient to activate LXR (Janowski et al. 1996;Smith 1996;Lehmann et al. 1997).