Biochemical and Biophysical Research Communications
Volume 171, Issue 3, 28 September 1990, Pages 1182-1187
Inhibition of myosin light chain phosphorylation in cultured smooth muscle cells by HA1077, a new type of vasodilator
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The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
2002, BloodCitation Excerpt :The inactive t-CA-4-P (0.1-10 µM) failed to induce any significant actin reorganization (data not shown). To determine whether the actin response to CA-4-P was due to the activation of Rho and Rho-kinase, cells were pretreated with the selective Rho inhibitor C3 exoenzyme from Clostridium botulinum33 (24 hours, 10 µg/mL; Figure 2C,D) or Rho-kinase inhibitors Y-2763230 (30 minutes, 10 µM; Figure 2E,F) and HA107742 (30 minutes, 10 µM; Figure2G,H) before CA-4-P addition. All inhibitors reduced microfilament assembly in resting cells to a small extent and completely blocked CA-4-P–mediated actin stress fiber formation.
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1993, European Journal of PharmacologyPossible prophylactic potential of HA1077, a Ca<sup>2+</sup> channel antagonist and vasodilator, on chronic cerebral vasospasm
1992, European Journal of Pharmacology
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